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6EUV

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (VX-787)

Summary for 6EUV
Entry DOI10.2210/pdb6euv/pdb
DescriptorPolymerase basic protein 2, (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, NICKEL (II) ION, ... (4 entities in total)
Functional Keywordsinfluenza a polymerase, pb2 subunit, cap-binding domain, cap-binding inhibitor, rna binding protein
Biological sourceInfluenza A virus (strain A/Victoria/3/1975 H3N2)
Cellular locationVirion : P31345
Total number of polymer chains4
Total formula weight132728.42
Authors
Cusack, S.,Lethier, M. (deposition date: 2017-10-31, release date: 2017-12-13, Last modification date: 2024-01-17)
Primary citationPflug, A.,Gaudon, S.,Resa-Infante, P.,Lethier, M.,Reich, S.,Schulze, W.M.,Cusack, S.
Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46:956-971, 2018
Cited by
PubMed: 29202182
DOI: 10.1093/nar/gkx1210
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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