6EUV

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (VX-787)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0039694	biological_process	viral RNA genome replication
C	0003723	molecular_function	RNA binding
C	0039694	biological_process	viral RNA genome replication
F	0003723	molecular_function	RNA binding
F	0039694	biological_process	viral RNA genome replication
I	0003723	molecular_function	RNA binding
I	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 21G A 601

Chain	Residue
A	PHE323
A	VAL511
A	LEU512
A	ARG355
A	HIS357
A	GLU361
A	LYS376
A	PHE404
A	GLN406
A	MET431
A	ASN510

---

site_id	AC2
Number of Residues	11
Details	binding site for residue 21G A 602

Chain	Residue
A	ALA278
A	LEU281
A	GLU282
A	HIS285
A	ARG293
A	ARG299
I	LEU281
I	GLU282
I	HIS285
I	ARG293
I	VAL295

---

site_id	AC3
Number of Residues	4
Details	binding site for residue NI A 603

Chain	Residue
A	HIS432
A	HOH710
A	HOH711
A	HOH718

---

site_id	AC4
Number of Residues	11
Details	binding site for residue 21G C 601

Chain	Residue
C	PHE323
C	ARG355
C	HIS357
C	GLU361
C	LYS376
C	PHE404
C	GLN406
C	MET431
C	ASN510
C	VAL511
C	LEU512

---

site_id	AC5
Number of Residues	12
Details	binding site for residue 21G C 602

Chain	Residue
C	ALA278
C	LEU281
C	GLU282
C	HIS285
C	ARG293
C	VAL295
F	ALA278
F	LEU281
F	GLU282
F	HIS285
F	ARG293
F	VAL295

---

site_id	AC6
Number of Residues	4
Details	binding site for residue NI C 603

Chain	Residue
C	HIS432
C	HOH716
C	HOH723
C	HOH725

---

site_id	AC7
Number of Residues	11
Details	binding site for residue 21G F 601

Chain	Residue
F	PHE323
F	ARG355
F	HIS357
F	GLU361
F	LYS376
F	PHE404
F	GLN406
F	MET431
F	ASN510
F	VAL511
F	LEU512

---

site_id	AC8
Number of Residues	3
Details	binding site for residue NI F 602

Chain	Residue
F	HIS432
F	HOH722
F	HOH725

---

site_id	AC9
Number of Residues	11
Details	binding site for residue 21G I 601

Chain	Residue
I	PHE323
I	ARG355
I	HIS357
I	GLU361
I	LYS376
I	PHE404
I	GLN406
I	MET431
I	ASN510
I	VAL511
I	LEU512

---

site_id	AD1
Number of Residues	4
Details	binding site for residue NI I 602

Chain	Residue
I	HIS432
I	HOH711
I	HOH715
I	HOH725

---