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7AW0

MerTK kinase domain in complex with purine inhibitor

Summary for 7AW0
Entry DOI10.2210/pdb7aw0/pdb
DescriptorTyrosine-protein kinase Mer, 2-(cyclopentyloxy)-9-(2,6-difluorobenzyl)-N-methyl-9H-purin-6-amine (3 entities in total)
Functional Keywordstyrosine kinase, inhibitor, type1 kinase inhibitor, structure-based drug design, oncology, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight34741.13
Authors
Primary citationNissink, J.W.M.,Bazzaz, S.,Blackett, C.,Clark, M.A.,Collingwood, O.,Disch, J.S.,Gikunju, D.,Goldberg, K.,Guilinger, J.P.,Hardaker, E.,Hennessy, E.J.,Jetson, R.,Keefe, A.D.,McCoull, W.,McMurray, L.,Olszewski, A.,Overman, R.,Pflug, A.,Preston, M.,Rawlins, P.B.,Rivers, E.,Schimpl, M.,Smith, P.,Truman, C.,Underwood, E.,Warwicker, J.,Winter-Holt, J.,Woodcock, S.,Zhang, Y.
Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy.
J.Med.Chem., 64:3165-3184, 2021
Cited by
PubMed: 33683117
DOI: 10.1021/acs.jmedchem.0c01904
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.893 Å)
Structure validation

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