5E6D
| Glucocorticoid receptor DNA binding domain - ICAM1 NF-kB response element complex | 分子名称: | DNA (5'-D(*GP*CP*TP*CP*CP*GP*GP*AP*AP*TP*TP*TP*CP*CP*AP*A)-3'), DNA (5'-D(*TP*TP*GP*GP*AP*AP*AP*TP*TP*CP*CP*GP*GP*AP*GP*C)-3'), Glucocorticoid receptor, ... | 著者 | Hudson, W.H, Rye, E.A, Herbst, A.G, Ortlund, E.A. | 登録日 | 2015-10-09 | 公開日 | 2017-02-08 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements. Nat Commun, 9, 2018
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5E6C
| Glucocorticoid receptor DNA binding domain - CCL2 NF-kB response element complex | 分子名称: | DNA (5'-D(*AP*GP*TP*GP*GP*AP*AP*AP*TP*TP*CP*CP*CP*AP*CP*T)-3'), DNA (5'-D(*AP*GP*TP*GP*GP*GP*AP*AP*TP*TP*TP*CP*CP*AP*CP*T)-3'), Glucocorticoid receptor, ... | 著者 | Hudson, W.H, Rye, E.A, Herbst, A.G, Ortlund, E.A. | 登録日 | 2015-10-09 | 公開日 | 2017-02-08 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements. Nat Commun, 9, 2018
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5E6B
| Glucocorticoid receptor DNA binding domain - RELB NF-kB response element complex | 分子名称: | DNA (5'-D(*CP*CP*GP*GP*GP*GP*AP*AP*TP*TP*CP*CP*GP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*CP*GP*GP*AP*AP*TP*TP*CP*CP*CP*CP*GP*G)-3'), Glucocorticoid receptor, ... | 著者 | Hudson, W.H, Rye, E.A, Herbst, A.G, Ortlund, E.A. | 登録日 | 2015-10-09 | 公開日 | 2017-02-08 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements. Nat Commun, 9, 2018
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5L0M
| hLRH-1 DNA Binding Domain - 12bp Oct4 promoter complex | 分子名称: | DNA (5'-D(*CP*TP*AP*GP*CP*CP*TP*TP*GP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*CP*AP*AP*GP*GP*CP*TP*AP*G)-3'), GLYCEROL, ... | 著者 | Tuntland, M.L, Ortlund, E.A. | 登録日 | 2016-07-27 | 公開日 | 2016-11-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.197 Å) | 主引用文献 | A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1). J. Mol. Biol., 428, 2016
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6CFN
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6C1Z
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5KRB
| GCNF DNA Binding Domain - Oct4 DR0 Complex | 分子名称: | DNA (5'-D(*AP*GP*AP*GP*GP*TP*CP*AP*AP*GP*GP*CP*TP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*AP*GP*CP*CP*TP*TP*GP*AP*CP*CP*TP*CP*T)-3'), Nuclear receptor subfamily 6 group A member 1, ... | 著者 | Weikum, E.R, Ortlund, E.A. | 登録日 | 2016-07-07 | 公開日 | 2016-11-09 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | 主引用文献 | A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1). J. Mol. Biol., 428, 2016
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5L11
| Human Liver Receptor Homologue-1 (LRH-1) Bound to RJW100 and a Fragment of TIF-2 | 分子名称: | (1R,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-1,2,3,3a,6,6a-hexahydropentalen-1-ol, Nuclear receptor subfamily 5 group A member 2, Tif2 | 著者 | Mays, S.G, Ortlund, E.A. | 登録日 | 2016-07-28 | 公開日 | 2016-10-12 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.849 Å) | 主引用文献 | Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists. J. Biol. Chem., 291, 2016
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5CC1
| S425G Glucocorticoid receptor DNA binding domain - (+)GRE complex | 分子名称: | DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), Glucocorticoid receptor, ... | 著者 | Hudson, W.H, Weikum, E.A, Ortlund, E.A. | 登録日 | 2015-07-01 | 公開日 | 2015-12-23 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.302 Å) | 主引用文献 | Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space. Proc.Natl.Acad.Sci.USA, 113, 2016
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5E6A
| Glucocorticoid receptor DNA binding domain - PLAU NF-kB response element complex | 分子名称: | DNA (5'-D(*AP*TP*CP*AP*GP*GP*AP*AP*AP*TP*TP*CP*CP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*GP*GP*AP*AP*TP*TP*TP*CP*CP*TP*GP*AP*T)-3'), Glucocorticoid receptor, ... | 著者 | Hudson, W.H, Rye, E.A, Herbst, A.G, Ortlund, E.A. | 登録日 | 2015-10-09 | 公開日 | 2017-02-08 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.197 Å) | 主引用文献 | Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements. Nat Commun, 9, 2018
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6W9M
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6W9L
| Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with deacetylated deflazacort and PGC1a coregulator fragment | 分子名称: | (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8-trimethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]oxazol-2-one, GLYCEROL, Glucocorticoid Receptor, ... | 著者 | Liu, X, Ortlund, E.A. | 登録日 | 2020-03-23 | 公開日 | 2020-11-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment. Proc.Natl.Acad.Sci.USA, 117, 2020
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6X6E
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6X6D
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6NWL
| Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with hydrocortisone and PGC1a coregulator fragment | 分子名称: | (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... | 著者 | Liu, X, Ortlund, E.A. | 登録日 | 2019-02-06 | 公開日 | 2019-10-23 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.595 Å) | 主引用文献 | First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain-Peroxisome Proliferator-ActivatedgammaCoactivator 1-alphaComplex with Endogenous and Synthetic Glucocorticoids. Mol.Pharmacol., 96, 2019
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8EYH
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8EYG
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6NWK
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8F4P
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6OQX
| Human Liver Receptor Homolog-1 bound to the agonist 5N and a fragment of the Tif2 coregulator | 分子名称: | (8beta,11alpha,12alpha)-8-(1-phenylethenyl)-1,6:7,14-dicycloprosta-1,3,5,7(14)-tetraen-11-yl sulfamate, Nuclear receptor coactivator 2, Nuclear receptor subfamily 5 group A member 2 | 著者 | Mays, S.G, Ortlund, E.A. | 登録日 | 2019-04-29 | 公開日 | 2019-08-28 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.004 Å) | 主引用文献 | Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design. J.Med.Chem., 62, 2019
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6OR1
| Human LRH-1 bound to the agonist 2N and a fragment of the Tif2 coregulator | 分子名称: | N-[(1S,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-1,2,3,3a,6,6a-hexahydropentalen-1-yl]acetamide, Nuclear receptor coactivator 2, Nuclear receptor subfamily 5 group A member 2 | 著者 | Mays, S.G, Ortlund, E.A. | 登録日 | 2019-04-29 | 公開日 | 2019-08-28 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.174 Å) | 主引用文献 | Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design. J.Med.Chem., 62, 2019
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8F8M
| LRH-1 bound to small molecule Tet and fragment of coactivator Tif2 | 分子名称: | (1~{R},3~{a}~{R},6~{a}~{R})-4-phenyl-3~{a}-(1-phenylethenyl)-5-[9-(1~{H}-1,2,3,4-tetrazol-5-yl)nonyl]-2,3,6,6~{a}-tetrahydro-1~{H}-pentalen-1-ol, Nuclear receptor coactivator 2, Nuclear receptor subfamily 5 group A member 2 | 著者 | Cato, M.L, Ortlund, E.A. | 登録日 | 2022-11-22 | 公開日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Isosteric improvements to liver receptor homolog-1 small molecule modulators To Be Published
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6OQY
| Human LRH-1 bound to the agonist 6N and a fragment of the Tif2 coregulator | 分子名称: | N-[(1S,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-1,2,3,3a,6,6a-hexahydropentalen-1-yl]sulfuric diamide, Nuclear receptor coactivator 2, Nuclear receptor subfamily 5 group A member 2 | 著者 | Mays, S.G, Ortlund, E.A. | 登録日 | 2019-04-29 | 公開日 | 2019-08-28 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design. J.Med.Chem., 62, 2019
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8GDR
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8GL7
| AncAR1 - progesterone - Tif2 | 分子名称: | Ancestral androgen receptor, GLYCEROL, Nuclear receptor coactivator 2, ... | 著者 | Little, M.M, Ortlund, E.A. | 登録日 | 2023-03-21 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Evolutionary tuning of a key helix drove androgen selectivity To Be Published
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