6W9M
Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with vamorolone and SHP coregulator fragment
Summary for 6W9M
| Entry DOI | 10.2210/pdb6w9m/pdb |
| Descriptor | Glucocorticoid Receptor, Nuclear receptor subfamily 0 group B member 2, vamorolone, ... (5 entities in total) |
| Functional Keywords | glucocorticoid receptor, anti-inflammation drug, hormone |
| Biological source | synthetic construct More |
| Total number of polymer chains | 2 |
| Total formula weight | 30709.79 |
| Authors | Liu, X.,Ortlund, E.A. (deposition date: 2020-03-23, release date: 2020-11-04, Last modification date: 2023-10-18) |
| Primary citation | Liu, X.,Wang, Y.,Gutierrez, J.S.,Damsker, J.M.,Nagaraju, K.,Hoffman, E.P.,Ortlund, E.A. Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment. Proc.Natl.Acad.Sci.USA, 117:24285-24293, 2020 Cited by PubMed: 32917814DOI: 10.1073/pnas.2006890117 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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