6W9M
Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with vamorolone and SHP coregulator fragment
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0004879 | molecular_function | nuclear receptor activity |
| A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| A | 0030518 | biological_process | nuclear receptor-mediated steroid hormone signaling pathway |
| A | 0034056 | molecular_function | estrogen response element binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue TUV A 301 |
| Chain | Residue |
| A | MET29 |
| A | PHE204 |
| A | CYS205 |
| A | THR208 |
| A | PHE218 |
| A | LEU32 |
| A | ASN33 |
| A | GLY36 |
| A | GLN39 |
| A | MET73 |
| A | ARG80 |
| A | PHE92 |
| A | GLN111 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | GLU9 |
| A | PRO10 |
| A | GLN39 |
| A | SER42 |
| A | TRP46 |
| A | MET73 |
| A | SER76 |
| A | LYS136 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | TYR67 |
| A | SER71 |
| A | THR143 |
| A | HIS195 |
| A | VAL198 |
| A | HOH418 |
