6W9M

Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with vamorolone and SHP coregulator fragment

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004879	molecular_function	nuclear receptor activity
A	0030518	biological_process	intracellular steroid hormone receptor signaling pathway
A	0034056	molecular_function	estrogen response element binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue TUV A 301

Chain	Residue
A	MET29
A	PHE204
A	CYS205
A	THR208
A	PHE218
A	LEU32
A	ASN33
A	GLY36
A	GLN39
A	MET73
A	ARG80
A	PHE92
A	GLN111

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site_id	AC2
Number of Residues	8
Details	binding site for residue GOL A 302

Chain	Residue
A	GLU9
A	PRO10
A	GLN39
A	SER42
A	TRP46
A	MET73
A	SER76
A	LYS136

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site_id	AC3
Number of Residues	6
Details	binding site for residue GOL A 303

Chain	Residue
A	TYR67
A	SER71
A	THR143
A	HIS195
A	VAL198
A	HOH418

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