6W9M
Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with vamorolone and SHP coregulator fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Glucocorticoid Receptor | polymer | 251 | 28964.7 | 1 | UniProt (A0A1X8XLE9) Pfam (PF00104) In PDB | synthetic construct | Ancestral Glucocorticoid Receptor2 |
| 2 | B | Nuclear receptor subfamily 0 group B member 2 | polymer | 11 | 1204.4 | 1 | UniProt (Q15466) In PDB | Homo sapiens | Orphan nuclear receptor SHP, Small heterodimer partner |
| 3 | A | vamorolone | non-polymer | 356.5 | 1 | Chemie (TUV) | vamorolone | ||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | water | water | 18.0 | 60 | Chemie (HOH) |
Sequence modifications
A: -1 - 245 (UniProt: A0A1X8XLE9)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Glu -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Lys 246 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30169.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 540.6 | |
| All* | Total formula weight | 30709.8 |
