6W9M
Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with vamorolone and SHP coregulator fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glucocorticoid Receptor | polymer | 251 | 28964.7 | 1 | UniProt (A0A1X8XLE9) | synthetic construct | Ancestral Glucocorticoid Receptor2 |
| 2 | B (B) | Nuclear receptor subfamily 0 group B member 2 | polymer | 11 | 1204.4 | 1 | UniProt (Q15466) | Homo sapiens | Orphan nuclear receptor SHP, Small heterodimer partner |
| 3 | C (A) | vamorolone | non-polymer | 356.5 | 1 | Chemie (TUV) PubChem (3035000) PubChem (496847) PubChem (22210339) PubChem (176540300) PubChem (46870386) PubChem (395352) PubChem (53373387) PubChem (54733079) PubChem (146156930) PubChem (59271753) PubChem (59271756) PubChem (117066284) PubChem (124389762) PubChem (124389763) PubChem (124489486) PubChem (124489487) PubChem (124489488) PubChem (124490063) PubChem (124936932) PubChem (125037016) PubChem (125037017) PubChem (125037018) PubChem (126969046) PubChem (139026161) PubChem (146632709) PubChem (164175027) PubChem (172015295) | vamorolone | ||
| 4 | D, E (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) PubChem (753) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 60 | Chemie (HOH) |
Sequence modifications
A: -1 - 245 (UniProt: A0A1X8XLE9)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Glu -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Lys 246 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30169.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 540.6 | |
| All* | Total formula weight | 30709.8 |
