8F8M

LRH-1 bound to small molecule Tet and fragment of coactivator Tif2

Summary for 8F8M

• Entry DOI: 10.2210/pdb8f8m/pdb
• Descriptor: Nuclear receptor subfamily 5 group A member 2, Nuclear receptor coactivator 2, (1~{R},3~{a}~{R},6~{a}~{R})-4-phenyl-3~{a}-(1-phenylethenyl)-5-[9-(1~{H}-1,2,3,4-tetrazol-5-yl)nonyl]-2,3,6,6~{a}-tetrahydro-1~{H}-pentalen-1-ol, ... (4 entities in total)
• Functional Keywords: lrh-1, nr5a2, nuclear receptor, liver receptor homolog-1, nuclear protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 30607.39

Authors

Cato, M.L.,Ortlund, E.A. (deposition date: 2022-11-22, release date: 2023-11-29)

• Primary citation: Cato, M.L.,Abraham, S.M.,Spurlin, R.M.,Flynn, A.R.,Colucci, J.K.,D'Agostino, E.H.,Johnson, A.M.,Jui, N.T.,Ortlund, E.A.; Isosteric improvements to liver receptor homolog-1 small molecule modulators; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.6 Å)