5L11

Human Liver Receptor Homologue-1 (LRH-1) Bound to RJW100 and a Fragment of TIF-2

Summary for 5L11

Entry DOI	10.2210/pdb5l11/pdb
Descriptor	Nuclear receptor subfamily 5 group A member 2, Tif2, (1R,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-1,2,3,3a,6,6a-hexahydropentalen-1-ol, ... (4 entities in total)
Functional Keywords	nuclear receptor, agonist, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	30426.19
Authors	Mays, S.G.,Ortlund, E.A. (deposition date: 2016-07-28, release date: 2016-10-12, Last modification date: 2023-10-04)
Primary citation	Mays, S.G.,Okafor, C.D.,Whitby, R.J.,Goswami, D.,Stec, J.,Flynn, A.R.,Dugan, M.C.,Jui, N.T.,Griffin, P.R.,Ortlund, E.A. Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists. J. Biol. Chem., 291:25281-25291, 2016 Cited by PubMed: 27694446 DOI: 10.1074/jbc.M116.753541 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.849 Å)

Structure validation