6OQX

Human Liver Receptor Homolog-1 bound to the agonist 5N and a fragment of the Tif2 coregulator

Summary for 6OQX

DescriptorNuclear receptor subfamily 5 group A member 2, Nuclear receptor coactivator 2, (8beta,11alpha,12alpha)-8-(1-phenylethenyl)-1,6:7,14-dicycloprosta-1,3,5,7(14)-tetraen-11-yl sulfamate, ... (4 entities in total)
Functional Keywordsnuclear hormone receptor, agonist, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight30606.38
Authors
Mays, S.G.,Ortlund, E.A. (deposition date: 2019-04-29, release date: 2019-08-28, Last modification date: 2020-01-08)
Primary citation
Mays, S.G.,Flynn, A.R.,Cornelison, J.L.,Okafor, C.D.,Wang, H.,Wang, G.,Huang, X.,Donaldson, H.N.,Millings, E.J.,Polavarapu, R.,Moore, D.D.,Calvert, J.W.,Jui, N.T.,Ortlund, E.A.
Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design.
J.Med.Chem., 62:11022-11034, 2019
PubMed: 31419141 (PDB entries with the same primary citation)
DOI: 10.1021/acs.jmedchem.9b00753
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.004 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2452 0.4% 2.7% 6.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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