6NWL
Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with hydrocortisone and PGC1a coregulator fragment
Summary for 6NWL
| Entry DOI | 10.2210/pdb6nwl/pdb |
| Descriptor | glucocorticoid receptor, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, ... (8 entities in total) |
| Functional Keywords | glucocorticoid receptor; agonist; coactivator, hormone |
| Biological source | Homo sapiens More |
| Total number of polymer chains | 2 |
| Total formula weight | 31187.47 |
| Authors | Liu, X.,Ortlund, E.A. (deposition date: 2019-02-06, release date: 2019-10-23, Last modification date: 2024-03-13) |
| Primary citation | Liu, X.,Wang, Y.,Ortlund, E.A. First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain-Peroxisome Proliferator-ActivatedgammaCoactivator 1-alphaComplex with Endogenous and Synthetic Glucocorticoids. Mol.Pharmacol., 96:408-417, 2019 Cited by PubMed: 31391291DOI: 10.1124/mol.119.116806 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.595 Å) |
Structure validation
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