6NWL

Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with hydrocortisone and PGC1a coregulator fragment

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue HCY A 301

Chain	Residue
A	LEU32
A	VAL216
A	PHE218
A	ASN33
A	GLN39
A	ARG80
A	PHE92
A	GLN111
A	PHE204
A	CYS205
A	THR208

---

site_id	AC2
Number of Residues	8
Details	binding site for residue GOL A 302

Chain	Residue
A	GLU9
A	VAL12
A	SER76
A	ARG80
A	TYR132
A	EPE305
A	GOL307
A	HOH447

---

site_id	AC3
Number of Residues	4
Details	binding site for residue GOL A 303

Chain	Residue
A	LYS83
A	ASN86
A	ASN86
A	ASN88

---

site_id	AC4
Number of Residues	10
Details	binding site for residue TLA A 304

Chain	Residue
A	TYR67
A	SER68
A	TRP69
A	MET70
A	SER71
A	THR143
A	HIS195
A	VAL198
A	LEU202
A	GLN229

---

site_id	AC5
Number of Residues	7
Details	binding site for residue EPE A 305

Chain	Residue
A	VAL12
A	TRP79
A	ARG80
A	LYS83
A	GLN84
A	GOL302
A	HOH413

---

site_id	AC6
Number of Residues	1
Details	binding site for residue SCN A 306

Chain	Residue
A	ARG159

---

site_id	AC7
Number of Residues	8
Details	binding site for residue GOL A 307

Chain	Residue
A	GLU9
A	PRO10
A	ALA43
A	TRP46
A	SER76
A	LYS136
A	GOL302
A	HOH458

---

site_id	AC8
Number of Residues	6
Details	binding site for residue SCN A 308

Chain	Residue
A	LYS189
A	ASP192
A	HIS244
A	GLN245
A	LYS246
A	HOH462

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Motif: {"description":"LXXLL motif","evidences":[{"source":"UniProtKB","id":"O70343","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O70343","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---