6NWL
Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with hydrocortisone and PGC1a coregulator fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | glucocorticoid receptor | polymer | 249 | 28778.5 | 1 | Homo sapiens | ||
| 2 | B (B) | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | polymer | 12 | 1265.6 | 1 | UniProt (Q9UBK2) | Homo sapiens | PPARGC-1-alpha,Ligand effect modulator 6 |
| 3 | C (A) | (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione | non-polymer | 362.5 | 1 | Chemie (HCY) | |||
| 4 | D, E, I (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | F (A) | L(+)-TARTARIC ACID | non-polymer | 150.1 | 1 | Chemie (TLA) | |||
| 6 | G (A) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 7 | H, J (A) | THIOCYANATE ION | non-polymer | 58.1 | 2 | Chemie (SCN) | |||
| 8 | K, L (A, B) | water | water | 18.0 | 90 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30044.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1143.3 | |
| All* | Total formula weight | 31187.5 |
