6W9L

Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with deacetylated deflazacort and PGC1a coregulator fragment

Summary for 6W9L

• Entry DOI: 10.2210/pdb6w9l/pdb
• Descriptor: Glucocorticoid Receptor, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8-trimethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]oxazol-2-one, ... (5 entities in total)
• Functional Keywords: glucocorticoid receptor, anti-inflammation drug, hormone
• Biological source: synthetic construct; More
• Total number of polymer chains: 2
• Total formula weight: 30535.74

Authors

Liu, X.,Ortlund, E.A. (deposition date: 2020-03-23, release date: 2020-11-04, Last modification date: 2023-10-18)

• Primary citation: Liu, X.,Wang, Y.,Gutierrez, J.S.,Damsker, J.M.,Nagaraju, K.,Hoffman, E.P.,Ortlund, E.A.; Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment.; Proc.Natl.Acad.Sci.USA, 117:24285-24293, 2020; PubMed: 32917814; DOI: 10.1073/pnas.2006890117

Experimental method

X-RAY DIFFRACTION (1.45 Å)