6W9L
Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with deacetylated deflazacort and PGC1a coregulator fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glucocorticoid Receptor | polymer | 249 | 28778.5 | 1 | UniProt (A0A1X8XLE9) Pfam (PF00104) | synthetic construct | Ancestral Glucocorticoid Receptor2 |
| 2 | B (B) | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha | polymer | 12 | 1265.6 | 1 | UniProt (Q9UBK2) | Homo sapiens | PPARGC-1-alpha,Ligand effect modulator 6 |
| 3 | C (A) | (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8-trimethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]oxazol-2-one | non-polymer | 399.5 | 1 | Chemie (TUS) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 171 | Chemie (HOH) |
Sequence modifications
A: -1 - 245 (UniProt: A0A1X8XLE9)
| PDB | External Database | Details |
|---|---|---|
| Phe -2 | - | expression tag |
| Lys 246 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30044.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 491.6 | |
| All* | Total formula weight | 30535.7 |
