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6OQY

Human LRH-1 bound to the agonist 6N and a fragment of the Tif2 coregulator

Summary for 6OQY
Entry DOI10.2210/pdb6oqy/pdb
DescriptorNuclear receptor subfamily 5 group A member 2, Nuclear receptor coactivator 2, N-[(1S,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-1,2,3,3a,6,6a-hexahydropentalen-1-yl]sulfuric diamide, ... (4 entities in total)
Functional Keywordsnuclear hormone receptor, agonist, transcription
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight30605.39
Authors
Mays, S.G.,Ortlund, E.A. (deposition date: 2019-04-29, release date: 2019-08-28, Last modification date: 2023-10-11)
Primary citationMays, S.G.,Flynn, A.R.,Cornelison, J.L.,Okafor, C.D.,Wang, H.,Wang, G.,Huang, X.,Donaldson, H.N.,Millings, E.J.,Polavarapu, R.,Moore, D.D.,Calvert, J.W.,Jui, N.T.,Ortlund, E.A.
Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design.
J.Med.Chem., 62:11022-11034, 2019
Cited by
PubMed: 31419141
DOI: 10.1021/acs.jmedchem.9b00753
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.23 Å)
Structure validation

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