7M10
| |
4QO4
| |
7Y9Z
| Cryo-EM structure of SARS-CoV-2 Omicron spike protein (S-6P-RRAR) in complex with human ACE2 ectodomain (one-RBD-up state) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | 著者 | Gao, G.F, Qi, J.X, Liu, S, Zhao, Z.N. | 登録日 | 2022-06-26 | 公開日 | 2022-09-21 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape. Nat Commun, 13, 2022
|
|
7YAD
| Cryo-EM structure of S309-RBD-RBD-S309 in the S309-bound Omicron spike protein (local refinement) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, S309 neutralizing antibody heavy chain, S309 neutralizing antibody light chain, ... | 著者 | Zhao, Z.N, Xie, Y.F, Qi, J.X, Gao, F. | 登録日 | 2022-06-27 | 公開日 | 2022-08-31 | 最終更新日 | 2022-09-07 | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | 主引用文献 | Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape. Nat Commun, 13, 2022
|
|
7Y9S
| Cryo-EM structure of apo SARS-CoV-2 Omicron spike protein (S-2P-GSAS) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Zhao, Z.N, Xie, Y.F, Qi, J.X, Gao, G.F. | 登録日 | 2022-06-26 | 公開日 | 2022-08-31 | 最終更新日 | 2022-09-07 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape. Nat Commun, 13, 2022
|
|
7YA1
| Cryo-EM structure of hACE2-bound SARS-CoV-2 Omicron spike protein with L371S, P373S and F375S mutations (local refinement) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | 著者 | Zhao, Z.N, Xie, Y.F, Qi, J.X, Gao, G.F. | 登録日 | 2022-06-27 | 公開日 | 2022-08-31 | 最終更新日 | 2022-09-07 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape. Nat Commun, 13, 2022
|
|
7YA0
| Cryo-EM structure of hACE2-bound SARS-CoV-2 Omicron spike protein with L371S, P373S and F375S mutations (S-6P-RRAR) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | 著者 | Zhao, Z.N, Xie, Y.F, Qi, J.X, Gao, G.F. | 登録日 | 2022-06-26 | 公開日 | 2022-09-21 | 最終更新日 | 2023-08-02 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape. Nat Commun, 13, 2022
|
|
8G05
| Cryo-EM structure of an orphan GPCR-Gi protein signaling complex | 分子名称: | 6-(octylamino)pyrimidine-2,4(3H,5H)-dione, CHOLESTEROL, G-protein coupled receptor 84, ... | 著者 | Zhang, X, Wang, Y.J, Li, X, Liu, G.B, Gong, W.M, Zhang, C. | 登録日 | 2023-01-31 | 公開日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Pro-phagocytic function and structural basis of GPR84 signaling. Nat Commun, 14, 2023
|
|
7V26
| XG005-bound SARS-CoV-2 S | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, XG005 Heavy chain, ... | 著者 | Zhan, W.Q, Zhang, X, Sun, L, Chen, Z.G. | 登録日 | 2021-08-07 | 公開日 | 2021-10-20 | 最終更新日 | 2022-07-06 | 実験手法 | ELECTRON MICROSCOPY (3.85 Å) | 主引用文献 | An ultrapotent pan-beta-coronavirus lineage B ( beta-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope. Protein Cell, 13, 2022
|
|
7V2A
| SARS-CoV-2 Spike trimer in complex with XG014 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, The heavy chain of XG014, ... | 著者 | Wang, K, Wang, X, Pan, L. | 登録日 | 2021-08-07 | 公開日 | 2021-10-20 | 最終更新日 | 2022-07-06 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | An ultrapotent pan-beta-coronavirus lineage B ( beta-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope. Protein Cell, 13, 2022
|
|
7DL3
| The structure of 3,5-DAHDHcca complex with NADPH | 分子名称: | 3,5-diaminohexanoate dehydrogenase, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Liu, N, Wu, L, Zhu, D.M, Zhou, J.H. | 登録日 | 2020-11-25 | 公開日 | 2021-09-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.84606934 Å) | 主引用文献 | Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids. Angew.Chem.Int.Ed.Engl., 60, 2021
|
|
7DL7
| The wild-type structure of 3,5-DAHDHcca | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3,5-diaminohexanoate dehydrogenase, ... | 著者 | Liu, N, Wu, L, Zhu, D.M, Zhou, J.H. | 登録日 | 2020-11-26 | 公開日 | 2021-09-29 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.30065823 Å) | 主引用文献 | Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids. Angew.Chem.Int.Ed.Engl., 60, 2021
|
|
7DL0
| The mutant E310G/A314Y of 3,5-DAHDHcca complex with NADPH | 分子名称: | 1,2-ETHANEDIOL, 3,5-diaminohexanoate dehydrogenase, CHLORIDE ION, ... | 著者 | Liu, N, Wu, L, Zhu, D.M, Zhou, J.H. | 登録日 | 2020-11-25 | 公開日 | 2021-09-29 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids. Angew.Chem.Int.Ed.Engl., 60, 2021
|
|
7DL1
| The mutant E310G/G323S structure of 3,5-DAHDHcca complex with NADPH | 分子名称: | 3,5-diaminohexanoate dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Liu, N, Wu, L, Zhu, D.M, Zhou, J.H. | 登録日 | 2020-11-25 | 公開日 | 2021-09-29 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | 主引用文献 | Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids. Angew.Chem.Int.Ed.Engl., 60, 2021
|
|
8HWT
| |
8HWS
| The complex structure of Omicron BA.4 RBD with BD604, S309, and S304 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BD-604 Fab Heavy chain, BD-604 Fab Light chain, ... | 著者 | He, Q.W, Xu, Z.P, Xie, Y.F. | 登録日 | 2023-01-02 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (2.36 Å) | 主引用文献 | An updated atlas of antibody evasion by SARS-CoV-2 Omicron sub-variants including BQ.1.1 and XBB. Cell Rep Med, 4, 2023
|
|
7VOC
| The crystal structure of a Radical SAM Enzyme BlsE involved in the Biosynthesis of Blasticidin S | 分子名称: | (2~{S},3~{S},4~{S},5~{R},6~{R})-6-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4,5-tris(oxidanyl)oxane-2-carboxylic acid, Cytosylglucuronate decarboxylase, GLYCEROL, ... | 著者 | Hou, X.L, Zhou, J.H. | 登録日 | 2021-10-13 | 公開日 | 2022-05-04 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.62005424 Å) | 主引用文献 | Radical S -Adenosyl Methionine Enzyme BlsE Catalyzes a Radical-Mediated 1,2-Diol Dehydration during the Biosynthesis of Blasticidin S. J.Am.Chem.Soc., 144, 2022
|
|
7VOB
| |
5GWD
| Structure of Myroilysin | 分子名称: | Myroilysin, ZINC ION | 著者 | Xu, D, Ran, T, Wang, W. | 登録日 | 2016-09-10 | 公開日 | 2017-02-15 | 最終更新日 | 2017-10-18 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Myroilysin Is a New Bacterial Member of the M12A Family of Metzincin Metallopeptidases and Is Activated by a Cysteine Switch Mechanism. J. Biol. Chem., 292, 2017
|
|
5I4V
| Discovery of novel, orally efficacious Liver X Receptor (LXR) beta agonists | 分子名称: | Oxysterols receptor LXR-beta,Nuclear receptor coactivator 2, Retinoic acid receptor RXR-beta,Nuclear receptor coactivator 2, {2-[(2R)-4-[4-(hydroxymethyl)-3-(methylsulfonyl)phenyl]-2-(propan-2-yl)piperazin-1-yl]-4-(trifluoromethyl)pyrimidin-5-yl}methanol | 著者 | Chen, G, McKeever, B.M. | 登録日 | 2016-02-12 | 公開日 | 2016-06-29 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) beta Agonist. J.Med.Chem., 59, 2016
|
|
4QOC
| |
7WZV
| The structure of a Twitch Radical SAM Dehydrogenase SpeY | 分子名称: | (1~{S},2~{R},4~{S},5~{R})-2,4-bis(methylamino)-6-[(2~{S},3~{R},4~{S},6~{R})-6-methyl-3,4-bis(oxidanyl)oxan-2-yl]oxy-cyclohexane-1,3,5-triol, 1,2-ETHANEDIOL, 4Fe-4S cluster-binding domain-containing protein, ... | 著者 | Zhou, J.H, Hou, X.L. | 登録日 | 2022-02-19 | 公開日 | 2022-12-28 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.899313 Å) | 主引用文献 | Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase. J.Am.Chem.Soc., 144, 2022
|
|
7WZX
| The structure of a Twitch Radical SAM Dehydrogenase SpeY | 分子名称: | (2~{S},4~{S},6~{R})-2-[(2~{S},3~{R},5~{S},6~{R})-3,5-bis(methylamino)-2,4,6-tris(oxidanyl)cyclohexyl]oxy-6-methyl-4-oxidanyl-oxan-3-one, 4Fe-4S cluster-binding domain-containing protein, GLYCEROL, ... | 著者 | Hou, X.L, Zhou, J.H. | 登録日 | 2022-02-19 | 公開日 | 2022-12-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.980013 Å) | 主引用文献 | Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase. J.Am.Chem.Soc., 144, 2022
|
|
7X0B
| The structure of a Twitch Radical SAM Dehydrogenase SpeY | 分子名称: | 4Fe-4S cluster-binding domain-containing protein, CHLORIDE ION, GLYCEROL, ... | 著者 | Hou, X.L, Zhou, J.H. | 登録日 | 2022-02-21 | 公開日 | 2022-12-28 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.02027535 Å) | 主引用文献 | Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase. J.Am.Chem.Soc., 144, 2022
|
|
3OBR
| |