3OBR

Crystal structure of Botulinum neurotoxin serotype D binding domain

Summary for 3OBR

• Entry DOI: 10.2210/pdb3obr/pdb
• Related: 3OBT
• Descriptor: Botulinum neurotoxin type D, GLYCEROL (3 entities in total)
• Functional Keywords: ligand binding, gangliosides, snares, hydrolase
• Biological source: Clostridium botulinum
• Cellular location: Botulinum neurotoxin D light chain: Secreted. Botulinum neurotoxin D heavy chain: Secreted: P19321
• Total number of polymer chains: 1
• Total formula weight: 51241.59

Authors

Zong, Y.,Lee, K.K.,Jin, R. (deposition date: 2010-08-09, release date: 2010-09-08, Last modification date: 2014-04-16)

• Primary citation: Strotmeier, J.,Lee, K.,Volker, A.K.,Mahrhold, S.,Zong, Y.,Zeiser, J.,Zhou, J.,Pich, A.,Bigalke, H.,Binz, T.,Rummel, A.,Jin, R.; Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.; Biochem.J., 431:207-216, 2010; PubMed: 20704566; DOI: 10.1042/BJ20101042

Experimental method

X-RAY DIFFRACTION (1.72 Å)