7YA1

Cryo-EM structure of hACE2-bound SARS-CoV-2 Omicron spike protein with L371S, P373S and F375S mutations (local refinement)

Summary for 7YA1

• Entry DOI: 10.2210/pdb7ya1/pdb
• EMDB information: 33699
• Descriptor: Angiotensin-converting enzyme 2, Spike protein S1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: sars-cov-2, omicron, spike protein, viral protein, hydrolase-viral protein complex, hydrolase/viral protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 92705.25

Authors

Zhao, Z.N.,Xie, Y.F.,Qi, J.X.,Gao, G.F. (deposition date: 2022-06-27, release date: 2022-08-31, Last modification date: 2022-09-07)

• Primary citation: Zhao, Z.,Zhou, J.,Tian, M.,Huang, M.,Liu, S.,Xie, Y.,Han, P.,Bai, C.,Han, P.,Zheng, A.,Fu, L.,Gao, Y.,Peng, Q.,Li, Y.,Chai, Y.,Zhang, Z.,Zhao, X.,Song, H.,Qi, J.,Wang, Q.,Wang, P.,Gao, G.F.; Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape.; Nat Commun, 13:4958-4958, 2022; PubMed: 36002453; DOI: 10.1038/s41467-022-32665-7

Experimental method

ELECTRON MICROSCOPY (3.11 Å)