7WZX

The structure of a Twitch Radical SAM Dehydrogenase SpeY

Summary for 7WZX

Entry DOI	10.2210/pdb7wzx/pdb
Descriptor	4Fe-4S cluster-binding domain-containing protein, IRON/SULFUR CLUSTER, S-ADENOSYLMETHIONINE, ... (7 entities in total)
Functional Keywords	spectinomycin, twitch radical sam dehydrogenase, epimerase, biosynthetic protein
Biological source	Streptomyces spectabilis
Total number of polymer chains	1
Total formula weight	38011.22
Authors	Hou, X.L.,Zhou, J.H. (deposition date: 2022-02-19, release date: 2022-12-28, Last modification date: 2023-11-29)
Primary citation	Zhang, J.,Hou, X.,Chen, Z.,Ko, Y.,Ruszczycky, M.W.,Chen, Y.,Zhou, J.,Liu, H.W. Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S -Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase. J.Am.Chem.Soc., 144:9910-9919, 2022 Cited by PubMed: 35622017 DOI: 10.1021/jacs.2c02676 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98001304567 Å)

Structure validation