7LV2
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3NEW
| p38-alpha complexed with Compound 10 | 分子名称: | 4-(trifluoromethyl)-3-[3-(trifluoromethyl)phenyl]-1,7-dihydro-6H-pyrazolo[3,4-b]pyridin-6-one, Mitogen-activated protein kinase 14 | 著者 | Goedken, E.R, Comess, K.M, Sun, C, Argiriadi, M, Jia, Y, Quinn, C.M, Banach, D.L, Marcotte, D, Borhani, D. | 登録日 | 2010-06-09 | 公開日 | 2010-12-01 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases. Acs Chem.Biol., 6, 2011
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6AJH
| Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with AU1235 | 分子名称: | (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, 1-(2-adamantyl)-3-[2,3,4-tris(fluoranyl)phenyl]urea, Drug exporters of the RND superfamily-like protein,Endolysin, ... | 著者 | Zhang, B, Li, J, Yang, X.L, Wu, L.J, Yang, H.T, Rao, Z.H. | 登録日 | 2018-08-27 | 公開日 | 2018-12-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.818 Å) | 主引用文献 | Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell, 176, 2019
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3O17
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6AJI
| Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with Rimonabant | 分子名称: | (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide, Drug exporters of the RND superfamily-like protein,Endolysin, ... | 著者 | Zhang, B, Li, J, Yang, X.L, Wu, L.J, Yang, H.T, Rao, Z.H. | 登録日 | 2018-08-27 | 公開日 | 2018-12-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target. Cell, 176, 2019
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3O2M
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8J18
| Cryo-EM structure of the 3-OH-C12-bound GPR84 receptor-Gi complex | 分子名称: | (3R)-3-HYDROXYDODECANOIC ACID, Antibody fragment ScFv16, G-protein coupled receptor 84, ... | 著者 | Liu, H, Yin, W, Xu, H.E. | 登録日 | 2023-04-12 | 公開日 | 2023-06-21 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84. Nat Commun, 14, 2023
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8J1A
| Cryo-EM structure of the GPR84 receptor-Gi complex with no ligand modeled | 分子名称: | Antibody fragment ScFv16, G-protein coupled receptor 84, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, H, Yin, W, Xu, H.E. | 登録日 | 2023-04-12 | 公開日 | 2023-06-21 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84. Nat Commun, 14, 2023
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8J19
| Cryo-EM structure of the LY237-bound GPR84 receptor-Gi complex | 分子名称: | 6-nonylpyridine-2,4-diol, Antibody fragment ScFv16, G-protein coupled receptor 84, ... | 著者 | Liu, H, Yin, W, Xu, H.E. | 登録日 | 2023-04-12 | 公開日 | 2023-06-21 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.23 Å) | 主引用文献 | Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84. Nat Commun, 14, 2023
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8JPC
| cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 2 | 分子名称: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-adrenergic receptor kinase 1, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | 登録日 | 2023-06-11 | 公開日 | 2023-08-09 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
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8JPD
| Focused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexes | 分子名称: | Beta-adrenergic receptor kinase 1, STAUROSPORINE | 著者 | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | 登録日 | 2023-06-11 | 公開日 | 2023-08-09 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
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8JPB
| cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 1 | 分子名称: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-adrenergic receptor kinase 1, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | 登録日 | 2023-06-11 | 公開日 | 2023-08-09 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
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8JPE
| Focused refinement structure of Galpha(q) in NTSR1-GRK2-Galpha(q) complexes | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ... | 著者 | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | 登録日 | 2023-06-11 | 公開日 | 2023-08-09 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | 主引用文献 | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
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8JPF
| Focused refiment structure of NTSR1 in NTSR1-GRK2-Galpha(q) complexes | 分子名称: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, NTS, Neurotensin receptor type 1 | 著者 | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | 登録日 | 2023-06-11 | 公開日 | 2023-08-09 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (3.02 Å) | 主引用文献 | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
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8J6J
| Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound with GSK256073 | 分子名称: | 8-chloranyl-3-pentyl-7H-purine-2,6-dione, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X. | 登録日 | 2023-04-26 | 公開日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2. Cell Rep, 42, 2023
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8J6I
| Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound MK-6892 | 分子名称: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X. | 登録日 | 2023-04-26 | 公開日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | 主引用文献 | Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2. Cell Rep, 42, 2023
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8J6L
| Cryo-EM structure of thehydroxycarboxylic acid receptor 2-Gi protein complex bound niacin | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Yuan, Q, Zhu, S, Duan, J, Xu, H.E, Duan, X. | 登録日 | 2023-04-26 | 公開日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2. Cell Rep, 42, 2023
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8DKB
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8DT5
| X-ray structure of human acetylcholinesterase ternary complex with paraoxon and oxime RS170B (POX-hAChE-RS170B) | 分子名称: | 4-carbamoyl-1-(3-{2-[(E)-(hydroxyimino)methyl]-1H-imidazol-1-yl}propyl)pyridin-1-ium, Acetylcholinesterase, DIETHYL PHOSPHONATE, ... | 著者 | Kovalevsky, A.Y, Gerlits, O, Radic, Z. | 登録日 | 2022-07-25 | 公開日 | 2022-11-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering. Structure, 30, 2022
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8DT2
| X-ray structure of human acetylcholinesterase inhibited by paraoxon (POX-hAChE) | 分子名称: | Acetylcholinesterase, DIETHYL PHOSPHONATE, DIMETHYL SULFOXIDE, ... | 著者 | Kovalevsky, A.Y, Gerlits, O, Radic, Z. | 登録日 | 2022-07-25 | 公開日 | 2022-11-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.803 Å) | 主引用文献 | Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering. Structure, 30, 2022
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8DT7
| X-ray structure of human acetylcholinesterase in complex with oxime MMB4 (hAChE-MMB4) | 分子名称: | 1,1'-methylenebis{4-[(E)-(hydroxyimino)methyl]pyridin-1-ium}, Acetylcholinesterase, GLYCEROL, ... | 著者 | Kovalevsky, A.Y, Gerlits, O, Radic, Z. | 登録日 | 2022-07-25 | 公開日 | 2022-11-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.207 Å) | 主引用文献 | Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering. Structure, 30, 2022
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8DT4
| X-ray structure of human acetylcholinesterase ternary complex with paraoxon and oxime MMB4 (POX-hAChE-MMB4) | 分子名称: | 1,1'-methylenebis{4-[(E)-(hydroxyimino)methyl]pyridin-1-ium}, Acetylcholinesterase, DIETHYL PHOSPHONATE, ... | 著者 | Kovalevsky, A.Y, Gerlits, O, Radic, Z. | 登録日 | 2022-07-25 | 公開日 | 2022-11-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural and dynamic effects of paraoxon binding to human acetylcholinesterase by X-ray crystallography and inelastic neutron scattering. Structure, 30, 2022
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5Z1V
| Crystal structure of AvrPib | 分子名称: | AvrPib protein | 著者 | Zhang, X, He, D, Zhao, Y.X, Taylor, I.A, Peng, Y.L, Yang, J, Liu, J.F. | 登録日 | 2017-12-28 | 公開日 | 2018-09-05 | 最終更新日 | 2018-10-03 | 実験手法 | X-RAY DIFFRACTION (1.661 Å) | 主引用文献 | A positive-charged patch and stabilized hydrophobic core are essential for avirulence function of AvrPib in the rice blast fungus. Plant J., 96, 2018
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5VGU
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8H8J
| Lodoxamide-bound GPR35 in complex with G13 | 分子名称: | 2,2'-[(2-chloro-5-cyano-1,3-phenylene)bis(azanediyl)]bis(oxoacetic acid), CALCIUM ION, CHOLESTEROL, ... | 著者 | Yuan, Q, Duan, J, Liu, Q, Xu, H.E, Jiang, Y. | 登録日 | 2022-10-23 | 公開日 | 2023-02-08 | 最終更新日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Insights into divalent cation regulation and G 13 -coupling of orphan receptor GPR35. Cell Discov, 8, 2022
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