PDB Search results for query - Protein Data Bank Japan

PDB: 3 results

Crystal Structure of human YEATS4 in complex with Pfizer small molecule compound 3b
Descriptor:	N-ethyl-1-{(3S,4S)-1-[(1-hydroxycyclohexyl)methyl]-3-methylpiperidin-4-yl}-2-methyl-1H-benzimidazole-5-carboxamide, YEATS domain-containing protein 4
Authors:	Dias, J.M, Byrnes, L.J, Varghese, A.H.
Deposit date:	2022-07-05
Release date:	2023-01-11
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (2.58 Å)
Cite:	Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4. J.Med.Chem., 66, 2023

Crystal Structure of BACE with Compound 14g
Descriptor:	4-{[(5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-2,2-dioxido-2-thia-1,3,8-triazaspiro[4.5]dec-8-yl]methyl}-2-(propan-2-yloxy)phenol, Beta-secretase 1, ZINC ION
Authors:	Vajdos, F.F, Varghese, A.H.
Deposit date:	2012-06-15
Release date:	2012-10-03
Last modified:	2013-06-19
Method:	X-RAY DIFFRACTION (1.56 Å)
Cite:	Spirocyclic sulfamides as beta-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitors. J.Med.Chem., 55, 2012

Crystal Structure of BACE with Compound 12a
Descriptor:	(5R,7S)-1-(3-fluorophenyl)-3,7-dimethyl-8-[3-(propan-2-yloxy)benzyl]-2-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide, 1,2-ETHANEDIOL, Beta-secretase 1, ...
Authors:	Vajdos, F.F, Varghese, A.H.
Deposit date:	2012-06-15
Release date:	2012-10-03
Last modified:	2013-06-19
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Spirocyclic sulfamides as beta-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitors. J.Med.Chem., 55, 2012