4YT6

Factor VIIa in complex with the inhibitor 4-{[(R)-[5-ethoxy-2-fluoro-3-(propan-2-yloxy)phenyl](4-phenyl-1H-imidazol-2-yl)methyl]amino}benzenecarboximidamide

Summary for 4YT6

• Entry DOI: 10.2210/pdb4yt6/pdb
• Related: 4YT7
• Descriptor: Coagulation factor VII (heavy chain), Coagulation factor VII (light chain), 4-[[(R)-(5-ethoxy-2-fluoranyl-3-propan-2-yloxy-phenyl)-(4-phenyl-1H-imidazol-2-yl)methyl]amino]benzenecarboximidamide, ... (7 entities in total)
• Functional Keywords: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P08709 P08709
• Total number of polymer chains: 2
• Total formula weight: 35563.55

Authors

Wei, A. (deposition date: 2015-03-17, release date: 2015-04-29, Last modification date: 2023-09-27)

• Primary citation: Glunz, P.W.,Cheng, X.,Cheney, D.L.,Weigelt, C.A.,Wei, A.,Luettgen, J.M.,Wong, P.C.,Wexler, R.R.,Priestley, E.S.; Design and synthesis of potent, selective phenylimidazole-based FVIIa inhibitors.; Bioorg.Med.Chem.Lett., 25:2169-2173, 2015; PubMed: 25881820; DOI: 10.1016/j.bmcl.2015.03.062

Experimental method

X-RAY DIFFRACTION (2.07 Å)