4X9J
EGR-1 with Doubly Methylated DNA
Summary for 4X9J
Entry DOI | 10.2210/pdb4x9j/pdb |
Related | 4R2A |
Descriptor | Early growth response protein 1, DNA (5'-D(*AP*GP*(5CM)P*GP*TP*GP*GP*GP*(5CM)P*GP*T)-3'), DNA (5'-D(*TP*AP*(5CM)P*GP*CP*CP*CP*AP*(5CM)P*GP*C)-3'), ... (5 entities in total) |
Functional Keywords | dna binding, methylated dna, zinc finger, transcription, transcription regulator-dna complex, transcription regulator/dna |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : P18146 |
Total number of polymer chains | 3 |
Total formula weight | 17684.02 |
Authors | White, M.A.,Zandarashvili, L.,Iwahara, J. (deposition date: 2014-12-11, release date: 2015-05-13, Last modification date: 2023-09-27) |
Primary citation | Zandarashvili, L.,White, M.A.,Esadze, A.,Iwahara, J. Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1. Febs Lett., 589:1748-1753, 2015 Cited by PubMed: 25999311DOI: 10.1016/j.febslet.2015.05.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.412 Å) |
Structure validation
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