4X9J
EGR-1 with Doubly Methylated DNA
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | CYS107 |
| A | CYS112 |
| A | HIS125 |
| A | HIS129 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 502 |
| Chain | Residue |
| A | CYS137 |
| A | CYS140 |
| A | HIS153 |
| A | HIS157 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 503 |
| Chain | Residue |
| A | CYS168 |
| A | HIS181 |
| A | HIS185 |
| A | CYS165 |
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 23 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. CpvesCdrrFsrsdeltrHiri..H |
| Chain | Residue | Details |
| A | CYS107-HIS129 | |
| A | CYS137-HIS157 | |
| A | CYS165-HIS185 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | ZN_FING: C2H2-type 1 => ECO:0000255|PROSITE-ProRule:PRU00042, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311, ECO:0007744|PDB:4R2A, ECO:0007744|PDB:4R2C, ECO:0007744|PDB:4R2D, ECO:0007744|PDB:4X9J |
| Chain | Residue | Details |
| A | TYR105-HIS129 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 22 |
| Details | ZN_FING: C2H2-type 2 => ECO:0000255|PROSITE-ProRule:PRU00042, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311, ECO:0007744|PDB:4R2A, ECO:0007744|PDB:4R2C, ECO:0007744|PDB:4R2D, ECO:0007744|PDB:4X9J |
| Chain | Residue | Details |
| A | PHE135-HIS157 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | ZN_FING: C2H2-type 3 => ECO:0000255|PROSITE-ProRule:PRU00042, ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311, ECO:0007744|PDB:4R2A, ECO:0007744|PDB:4R2C, ECO:0007744|PDB:4R2D, ECO:0007744|PDB:4X9J |
| Chain | Residue | Details |
| A | PHE163-HIS185 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Interaction with DNA => ECO:0000269|PubMed:25258363, ECO:0007744|PDB:4R2A |
| Chain | Residue | Details |
| A | ARG103 | |
| A | ARG124 | |
| A | ARG146 | |
| A | ARG174 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | SITE: Interaction with DNA => ECO:0000250|UniProtKB:P08046 |
| Chain | Residue | Details |
| A | ARG114 | |
| A | ARG118 | |
| A | ARG142 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Interaction with DNA => ECO:0000269|PubMed:25999311, ECO:0007744|PDB:4X9J |
| Chain | Residue | Details |
| A | ARG170 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | SITE: Interaction with DNA => ECO:0000269|PubMed:25258363, ECO:0000269|PubMed:25999311, ECO:0007744|PDB:4R2A, ECO:0007744|PDB:4X9J |
| Chain | Residue | Details |
| A | ARG180 |
