9B4J

Filament of D-TLKIVWS, a D-peptide that disaggregates Alzheimer's Paired Helical Filaments, determined by Cryo-EM

Summary for 9B4J

• Entry DOI: 10.2210/pdb9b4j/pdb
• Related: 9B4I 9B4K
• EMDB information: 44182
• Descriptor: DTH-DLE-DLY-DIL-DVA-DTR-DSN (1 entity in total)
• Functional Keywords: alzheimer's disease, tau, fibril, cryo-em, helix, unknown function
• Biological source: synthetic construct
• Total number of polymer chains: 60
• Total formula weight: 50761.56

Authors

Hou, K.,Ge, P.,Sawaya, M.R.,Eisenberg, D.S. (deposition date: 2024-03-20, release date: 2025-03-12, Last modification date: 2025-07-09)

• Primary citation: Hou, K.,Ge, P.,Sawaya, M.R.,Lutter, L.,Dolinsky, J.L.,Yang, Y.,Jiang, Y.X.,Boyer, D.R.,Cheng, X.,Pi, J.,Zhang, J.,Lu, J.,Abskharon, R.,Yang, S.,Yu, Z.,Feigon, J.,Eisenberg, D.S.; How short peptides disassemble tau fibrils in Alzheimer's disease; Nature, 2025; DOI: 10.1038/s41586-025-09244-z

Experimental method

ELECTRON MICROSCOPY (3.5 Å)