5Y8W
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![BU of 5y8w by Molmil](/molmil-images/mine/5y8w) | Crystal Structure Analysis of the BRD4 | 分子名称: | 1,2-ETHANEDIOL, 5-bromanyl-2-methoxy-N-(3-methyl-6-oxidanyl-1,2-benzoxazol-5-yl)benzenesulfonamide, Bromodomain-containing protein 4, ... | 著者 | Xu, Y, Zhang, Y, Song, M, Wang, C. | 登録日 | 2017-08-21 | 公開日 | 2018-06-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC) J. Med. Chem., 61, 2018
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5Y94
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![BU of 5y94 by Molmil](/molmil-images/mine/5y94) | Crystal Structure Analysis of the BRD4 | 分子名称: | 5-bromanyl-2-methoxy-N-[3-methyl-6-(methylamino)-1,2-benzoxazol-5-yl]benzenesulfonamide, Bromodomain-containing protein 4, GLYCEROL, ... | 著者 | Xu, Y, Zhang, Y, Song, M, Wang, C. | 登録日 | 2017-08-22 | 公開日 | 2018-06-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC) J. Med. Chem., 61, 2018
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5Y8Z
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![BU of 5y8z by Molmil](/molmil-images/mine/5y8z) | Crystal Structure Analysis of the BRD4 | 分子名称: | 1,2-ETHANEDIOL, 5-bromanyl-N-(3,6-dimethyl-1,2-benzoxazol-5-yl)-2-methoxy-benzenesulfonamide, Bromodomain-containing protein 4, ... | 著者 | Xu, Y, Zhang, Y, Song, M, Wang, C. | 登録日 | 2017-08-22 | 公開日 | 2018-06-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC) J. Med. Chem., 61, 2018
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8SAI
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![BU of 8sai by Molmil](/molmil-images/mine/8sai) | Cryo-EM structure of GPR34-Gi complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Yong, X.H, Zhao, C, Yan, W, Shao, Z.H. | 登録日 | 2023-04-01 | 公開日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Cryo-EM structures of human GPR34 enable the identification of selective antagonists. Proc.Natl.Acad.Sci.USA, 120, 2023
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6ZY3
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![BU of 6zy3 by Molmil](/molmil-images/mine/6zy3) | Cryo-EM structure of MlaFEDB in complex with phospholipid | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ABC transporter maintaining OM lipid asymmetry, cytoplasmic STAS component, ... | 著者 | Dong, C.J, Dong, H.H. | 登録日 | 2020-07-30 | 公開日 | 2020-11-25 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB. Nat.Struct.Mol.Biol., 28, 2021
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6ZY4
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![BU of 6zy4 by Molmil](/molmil-images/mine/6zy4) | Cryo-EM structure of MlaFEDB in complex with ADP | 分子名称: | ABC transporter maintaining OM lipid asymmetry, cytoplasmic STAS component, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Dong, C.J, Dong, H.H. | 登録日 | 2020-07-30 | 公開日 | 2020-11-25 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB. Nat.Struct.Mol.Biol., 28, 2021
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6ZY2
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![BU of 6zy2 by Molmil](/molmil-images/mine/6zy2) | Cryo-EM structure of apo MlaFEDB | 分子名称: | ABC transporter maintaining OM lipid asymmetry, cytoplasmic STAS component, Toluene tolerance protein Ttg2A, ... | 著者 | Dong, C.J, Dong, H.H. | 登録日 | 2020-07-30 | 公開日 | 2020-11-25 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB. Nat.Struct.Mol.Biol., 28, 2021
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6ZY9
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![BU of 6zy9 by Molmil](/molmil-images/mine/6zy9) | Cryo-EM structure of MlaFEDB in complex with AMP-PNP | 分子名称: | ABC transporter maintaining OM lipid asymmetry, cytoplasmic STAS component, MAGNESIUM ION, ... | 著者 | Dong, C.J, Dong, H.H. | 登録日 | 2020-07-30 | 公開日 | 2020-11-25 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB. Nat.Struct.Mol.Biol., 28, 2021
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8JGG
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![BU of 8jgg by Molmil](/molmil-images/mine/8jgg) | CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist BAM8-22 | 分子名称: | BAM8-22, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Sun, J.P, Xu, H.E, Ynag, F, Liu, Z.M, Guo, L.L, Zhang, Y.M, Fang, G.X, Tie, L, Zhuang, Y.M, Xue, C.Y. | 登録日 | 2023-05-20 | 公開日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nat Commun, 14, 2023
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8JGB
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![BU of 8jgb by Molmil](/molmil-images/mine/8jgb) | CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist CNF-Tx2 | 分子名称: | Conorfamide-Tx2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Sun, J.P, Xu, H.E, Yang, F, Liu, Z.M, Guo, L.L, Zhang, Y.M, Fang, G.X, Tie, L, Zhuang, Y.M, Xue, C.Y. | 登録日 | 2023-05-20 | 公開日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nat Commun, 14, 2023
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8JGF
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![BU of 8jgf by Molmil](/molmil-images/mine/8jgf) | CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22 | 分子名称: | BAM8-22, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Sun, J.P, Xu, H.E, Yang, F, Liu, Z.M, Guo, L.L, Zhang, Y.M, Fang, G.X, Tie, L, Zhuang, Y.M, Xue, C.Y. | 登録日 | 2023-05-20 | 公開日 | 2024-01-10 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nat Commun, 14, 2023
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5XXH
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![BU of 5xxh by Molmil](/molmil-images/mine/5xxh) | Crystal Structure Analysis of the CBP | 分子名称: | (3S)-1-[2-(3-ethanoylindol-1-yl)ethanoyl]piperidine-3-carboxylic acid, 1,2-ETHANEDIOL, CREB-binding protein, ... | 著者 | Xiang, Q, Zhang, Y, Wang, C, Song, M. | 登録日 | 2017-07-04 | 公開日 | 2018-06-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer. Eur J Med Chem, 147, 2018
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5H25
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![BU of 5h25 by Molmil](/molmil-images/mine/5h25) | EED in complex with PRC2 allosteric inhibitor compound 11 | 分子名称: | 5-(2-fluorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H. | 登録日 | 2016-10-14 | 公開日 | 2017-01-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | 主引用文献 | Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy J. Med. Chem., 60, 2017
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5H19
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![BU of 5h19 by Molmil](/molmil-images/mine/5h19) | EED in complex with PRC2 allosteric inhibitor EED162 | 分子名称: | 5-(furan-2-ylmethylamino)-9-(phenylmethyl)-8,10-dihydro-7H-[1,2,4]triazolo[3,4-a][2,7]naphthyridine-6-carbonitrile, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H. | 登録日 | 2016-10-08 | 公開日 | 2017-01-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED PLoS ONE, 12, 2017
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5YQX
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![BU of 5yqx by Molmil](/molmil-images/mine/5yqx) | Crystal Structure Analysis of the BRD4 | 分子名称: | (2R)-2-(cyclopropylmethyl)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-4H-1,4-benzoxazin-3-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ... | 著者 | Xue, X, Zhang, Y, Wang, C, Song, M. | 登録日 | 2017-11-08 | 公開日 | 2018-11-28 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer. Eur.J.Med.Chem., 152, 2018
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5H24
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![BU of 5h24 by Molmil](/molmil-images/mine/5h24) | EED in complex with PRC2 allosteric inhibitor compound 8 | 分子名称: | 5-(furan-2-ylmethylamino)-[1,2,4]triazolo[4,3-a]pyridine-6-carbonitrile, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H. | 登録日 | 2016-10-14 | 公開日 | 2017-01-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy J. Med. Chem., 60, 2017
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5GSA
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![BU of 5gsa by Molmil](/molmil-images/mine/5gsa) | EED in complex with an allosteric PRC2 inhibitor | 分子名称: | Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, Polycomb protein EED | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H. | 登録日 | 2016-08-15 | 公開日 | 2017-02-01 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of Nat. Chem. Biol., 13, 2017
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8I6K
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![BU of 8i6k by Molmil](/molmil-images/mine/8i6k) | Structure of hMNDA HIN with dsDNA | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*GP*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3'), ... | 著者 | Li, Y.L, Jin, T.C. | 登録日 | 2023-01-28 | 公開日 | 2023-07-19 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural mechanism of dsDNA recognition by the hMNDA HIN domain: New insights into the DNA-binding model of a PYHIN protein. Int.J.Biol.Macromol., 245, 2023
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5Y8C
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![BU of 5y8c by Molmil](/molmil-images/mine/5y8c) | Crystal Structure Analysis of the BRD4 | 分子名称: | 1,2-ETHANEDIOL, 5-chloranyl-2-methoxy-N-(6-methoxy-3-methyl-1,2-benzoxazol-5-yl)benzenesulfonamide, Bromodomain-containing protein 4, ... | 著者 | Xu, Y, Zhang, Y, Song, M, Wang, C. | 登録日 | 2017-08-21 | 公開日 | 2018-06-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC) J. Med. Chem., 61, 2018
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4RZV
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![BU of 4rzv by Molmil](/molmil-images/mine/4rzv) | |
4RZW
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![BU of 4rzw by Molmil](/molmil-images/mine/4rzw) | Crystal structure of BRAF (R509H) kinase domain bound to AZ628 | 分子名称: | 3-(2-cyanopropan-2-yl)-N-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide, Serine/threonine-protein kinase B-raf | 著者 | Wu, Y, Gavathiotis, E. | 登録日 | 2014-12-24 | 公開日 | 2016-08-10 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.493 Å) | 主引用文献 | An integrated model of RAF inhibitor action predicts
inhibitor activity against oncogenic BRAF signaling Cancer Cell, 30, 2016
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8HF2
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![BU of 8hf2 by Molmil](/molmil-images/mine/8hf2) | Cryo-EM structure of WeiTsing | 分子名称: | PRA1 family protein | 著者 | Qin, L, Tang, L.H, Chen, Y.H. | 登録日 | 2022-11-09 | 公開日 | 2023-06-21 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (4.14 Å) | 主引用文献 | WeiTsing, a pericycle-expressed ion channel, safeguards the stele to confer clubroot resistance. Cell, 186, 2023
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8WD8
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![BU of 8wd8 by Molmil](/molmil-images/mine/8wd8) | Cryo-EM structure of TtdAgo-guide DNA-target DNA complex | 分子名称: | Argonaute family protein, Guide DNA, MAGNESIUM ION, ... | 著者 | Zhuang, L. | 登録日 | 2023-09-14 | 公開日 | 2024-01-31 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonaute. Mol.Cell, 84, 2024
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8WCE
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![BU of 8wce by Molmil](/molmil-images/mine/8wce) | Cryo-EM structure of a protein-RNA complex | 分子名称: | MAGNESIUM ION, RNA (31-MER), RNA (66-MER), ... | 著者 | Li, Z. | 登録日 | 2023-09-11 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Molecular mechanism for target RNA recognition and cleavage of Cas13h. Nucleic Acids Res., 52, 2024
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8X3R
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![BU of 8x3r by Molmil](/molmil-images/mine/8x3r) | |