5GSA

EED in complex with an allosteric PRC2 inhibitor

Summary for 5GSA

Entry DOI	10.2210/pdb5gsa/pdb
Descriptor	Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ... (4 entities in total)
Functional Keywords	eed, prc2, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus: O75530 Q15910
Total number of polymer chains	4
Total formula weight	92695.62
Authors	Zhao, K.,Zhao, M.,Luo, X.,Zhang, H. (deposition date: 2016-08-15, release date: 2017-02-01, Last modification date: 2023-11-08)
Primary citation	Qi, W.,Zhao, K.,Gu, J.,Huang, Y.,Wang, Y.,Zhang, H.,Zhang, M.,Zhang, J.,Yu, Z.,Li, L.,Teng, L.,Chuai, S.,Zhang, C.,Zhao, M.,Chan, H.,Chen, Z.,Fang, D.,Fei, Q.,Feng, L.,Feng, L.,Gao, Y.,Ge, H.,Ge, X.,Li, G.,Lingel, A.,Lin, Y.,Liu, Y.,Luo, F.,Shi, M.,Wang, L.,Wang, Z.,Yu, Y.,Zeng, J.,Zeng, C.,Zhang, L.,Zhang, Q.,Zhou, S.,Oyang, C.,Atadja, P.,Li, E. An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of Nat. Chem. Biol., 13:381-388, 2017 Cited by PubMed: 28135235 DOI: 10.1038/nchembio.2304 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.49 Å)

Structure validation