5GSA
EED in complex with an allosteric PRC2 inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Polycomb protein EED | polymer | 367 | 42356.2 | 2 | UniProt (O75530) Pfam (PF00400) In PDB | Homo sapiens (Human) | hEED,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
2 | C, D | Histone-lysine N-methyltransferase EZH2 | polymer | 29 | 3622.2 | 2 | UniProt (Q15910) Pfam (PF11616) In PDB | Homo sapiens | ENX-1,Enhancer of zeste homolog 2,Lysine N-methyltransferase 6 |
3 | A, B | N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine | non-polymer | 369.4 | 2 | Chemie (73K) | |||
4 | water | water | 18.0 | 180 | Chemie (HOH) |
Sequence modifications
A, B: 76 - 441 (UniProt: O75530)
PDB | External Database | Details |
---|---|---|
Gly 75 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 91956.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 738.8 | |
All* | Total formula weight | 92695.6 |