5Y94

Crystal Structure Analysis of the BRD4

Summary for 5Y94

• Entry DOI: 10.2210/pdb5y94/pdb
• Descriptor: Bromodomain-containing protein 4, 5-bromanyl-2-methoxy-N-[3-methyl-6-(methylamino)-1,2-benzoxazol-5-yl]benzenesulfonamide, NITRATE ION, ... (6 entities in total)
• Functional Keywords: brd4(1), bromodomain, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 17432.71

Authors

Xu, Y.,Zhang, Y.,Song, M.,Wang, C. (deposition date: 2017-08-22, release date: 2018-06-13, Last modification date: 2024-03-27)

• Primary citation: Zhang, M.,Zhang, Y.,Song, M.,Xue, X.,Wang, J.,Wang, C.,Zhang, C.,Li, C.,Xiang, Q.,Zou, L.,Wu, X.,Wu, C.,Dong, B.,Xue, W.,Zhou, Y.,Chen, H.,Wu, D.,Ding, K.,Xu, Y.; Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC); J. Med. Chem., 61:3037-3058, 2018; PubMed: 29566488; DOI: 10.1021/acs.jmedchem.8b00103

Experimental method

X-RAY DIFFRACTION (2 Å)