4RZW

Crystal structure of BRAF (R509H) kinase domain bound to AZ628

Summary for 4RZW

• Entry DOI: 10.2210/pdb4rzw/pdb
• Related: 4RZV
• Descriptor: Serine/threonine-protein kinase B-raf, 3-(2-cyanopropan-2-yl)-N-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide (2 entities in total)
• Functional Keywords: transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : P15056
• Total number of polymer chains: 2
• Total formula weight: 64930.39

Authors

Wu, Y.,Gavathiotis, E. (deposition date: 2014-12-24, release date: 2016-08-10, Last modification date: 2023-09-20)

• Primary citation: Karoulia, Z.,Wu, Y.,Ahmed, T.A.,Qisheng, X.,Bollard, J.,Krepler, C.,Wu, X.,Zhang, C.,Bollag, G.,Herlym, M.,Fagin, J.A.,Lujambio, A.,Gavathiotis, E.,Poulikakos, P.I.; An integrated model of RAF inhibitor action predicts inhibitor activity against oncogenic BRAF signaling; Cancer Cell, 30:1-14, 2016

Experimental method

X-RAY DIFFRACTION (3.493 Å)