4RZW
Crystal structure of BRAF (R509H) kinase domain bound to AZ628
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Serine/threonine-protein kinase B-raf | polymer | 281 | 32013.7 | 2 | UniProt (P15056) Pfam (PF07714) In PDB | Homo sapiens (human) | Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1 |
2 | A, B | 3-(2-cyanopropan-2-yl)-N-{4-methyl-3-[(3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino]phenyl}benzamide | non-polymer | 451.5 | 2 | Chemie (B1E) |
Sequence modifications
A, B: 443 - 723 (UniProt: P15056)
PDB | External Database | Details |
---|---|---|
His 509 | Arg 509 | engineered mutation |
Ala 543 | Ile 543 | engineered mutation |
Ser 544 | Ile 544 | engineered mutation |
Lys 551 | Ile 551 | engineered mutation |
Arg 562 | Gln 562 | engineered mutation |
Asn 588 | Leu 588 | engineered mutation |
Ser 630 | Lys 630 | engineered mutation |
Glu 667 | Phe 667 | engineered mutation |
Ser 673 | Tyr 673 | engineered mutation |
Arg 688 | Ala 688 | engineered mutation |
Ser 706 | Leu 706 | engineered mutation |
Arg 709 | Gln 709 | engineered mutation |
Glu 713 | Ser 713 | engineered mutation |
Glu 716 | Leu 716 | engineered mutation |
Glu 720 | Ser 720 | engineered mutation |
Ser 722 | Pro 722 | engineered mutation |
Gly 723 | Lys 723 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 64027.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 903.0 | |
All* | Total formula weight | 64930.4 |