5YQX

Crystal Structure Analysis of the BRD4

Summary for 5YQX

Entry DOI	10.2210/pdb5yqx/pdb
Descriptor	Bromodomain-containing protein 4, (2R)-2-(cyclopropylmethyl)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-4H-1,4-benzoxazin-3-one, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	bet, brd4, bromodomain, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	17090.71
Authors	Xue, X.,Zhang, Y.,Wang, C.,Song, M. (deposition date: 2017-11-08, release date: 2018-11-28, Last modification date: 2024-03-27)
Primary citation	Xue, X.,Zhang, Y.,Wang, C.,Zhang, M.,Xiang, Q.,Wang, J.,Wang, A.,Li, C.,Zhang, C.,Zou, L.,Wang, R.,Wu, S.,Lu, Y.,Chen, H.,Ding, K.,Li, G.,Xu, Y. Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer. Eur.J.Med.Chem., 152:542-559, 2018 Cited by PubMed: 29758518 DOI: 10.1016/j.ejmech.2018.04.034 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.82 Å)

Structure validation