8JGB

CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist CNF-Tx2

Summary for 8JGB

Entry DOI	10.2210/pdb8jgb/pdb
EMDB information	36229
Descriptor	Conorfamide-Tx2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... (6 entities in total)
Functional Keywords	itch receptor, mas-related gpcrs, mgprx1, structural protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	6
Total formula weight	154819.74
Authors	Sun, J.P.,Xu, H.E.,Yang, F.,Liu, Z.M.,Guo, L.L.,Zhang, Y.M.,Fang, G.X.,Tie, L.,Zhuang, Y.M.,Xue, C.Y. (deposition date: 2023-05-20, release date: 2024-01-10)
Primary citation	Guo, L.,Zhang, Y.,Fang, G.,Tie, L.,Zhuang, Y.,Xue, C.,Liu, Q.,Zhang, M.,Zhu, K.,You, C.,Xu, P.,Yuan, Q.,Zhang, C.,Liu, L.,Rong, N.,Peng, S.,Liu, Y.,Wang, C.,Luo, X.,Lv, Z.,Kang, D.,Yu, X.,Zhang, C.,Jiang, Y.,Dong, X.,Zhou, J.,Liu, Z.,Yang, F.,Eric Xu, H.,Sun, J.P. Ligand recognition and G protein coupling of the human itch receptor MRGPRX1. Nat Commun, 14:5004-5004, 2023 Cited by PubMed: 37591889 DOI: 10.1038/s41467-023-40705-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.84 Å)

Structure validation