7ALZ
| GqqA- a novel type of quorum quenching acylases | 分子名称: | PHENYLALANINE, Prephenate dehydratase | 著者 | Werner, N, Betzel, C. | 登録日 | 2020-10-07 | 公開日 | 2021-08-04 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | The Komagataeibacter europaeus GqqA is the prototype of a novel bifunctional N-Acyl-homoserine lactone acylase with prephenate dehydratase activity. Sci Rep, 11, 2021
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7AM0
| GqqA- a novel type of quorum quenching acylases | 分子名称: | PHENYLALANINE, Prephenate dehydratase | 著者 | Werner, N, Betzel, C. | 登録日 | 2020-10-07 | 公開日 | 2021-08-04 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The Komagataeibacter europaeus GqqA is the prototype of a novel bifunctional N-Acyl-homoserine lactone acylase with prephenate dehydratase activity. Sci Rep, 11, 2021
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2QB5
| Crystal Structure of Human Inositol 1,3,4-Trisphosphate 5/6-Kinase (ITPK1) in Complex with ADP and Mn2+ | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Inositol-tetrakisphosphate 1-kinase, MANGANESE (II) ION, ... | 著者 | Chamberlain, P.P, Lesley, S.A, Spraggon, G. | 登録日 | 2007-06-15 | 公開日 | 2007-07-03 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Integration of inositol phosphate signaling pathways via human ITPK1. J.Biol.Chem., 282, 2007
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1QUZ
| Solution structure of the potassium channel scorpion toxin HSTX1 | 分子名称: | HSTX1 TOXIN | 著者 | Savarin, P, Romi-Lebrun, R, Zinn-Justin, S, Lebrun, B, Nakajima, T, Gilquin, B, Menez, A. | 登録日 | 1999-07-05 | 公開日 | 2000-07-07 | 最終更新日 | 2022-03-02 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and functional consequences of the presence of a fourth disulfide bridge in the scorpion short toxins: solution structure of the potassium channel inhibitor HsTX1. Protein Sci., 8, 1999
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8OYS
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8OYV
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8OYX
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8OYW
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8OYY
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8D8R
| SARS-CoV-2 Spike RBD in complex with DMAb 2196 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2196 heavy chain, 2196 light chain, ... | 著者 | Du, J, Cui, J, Pallesen, J. | 登録日 | 2022-06-08 | 公開日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2. Nat Commun, 13, 2022
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8D8Q
| SARS-CoV-2 Spike RBD in complex with DMAbs 2130 and 2196 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2130 heavy chain, 2130 light chain, ... | 著者 | Du, J, Cui, J, Pallesen, J. | 登録日 | 2022-06-08 | 公開日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2. Nat Commun, 13, 2022
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6WXJ
| CSF1R signaling is a regulator of pathogenesis in progressive MS | 分子名称: | 4-(3-{[(2S)-2-(6-methoxypyridin-3-yl)-2,3-dihydro-1,4-benzodioxin-6-yl]methyl}-3H-imidazo[4,5-b]pyridin-6-yl)-2-methylbut-3-yn-2-amine, Macrophage colony-stimulating factor 1 receptor | 著者 | Liu, J. | 登録日 | 2020-05-10 | 公開日 | 2021-02-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | CSF1R signaling is a regulator of pathogenesis in progressive MS. Cell Death Dis, 11, 2020
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8G0M
| Structure of complex between TV6.6 and CD98hc ECD | 分子名称: | 1,2-ETHANEDIOL, 4F2 cell-surface antigen heavy chain, TETRAETHYLENE GLYCOL, ... | 著者 | Kariolis, M.S, Lexa, K, Liau, N.P.D, Srivastava, D, Tran, H, Wells, R.C. | 登録日 | 2023-01-31 | 公開日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | CD98hc is a target for brain delivery of biotherapeutics. Nat Commun, 14, 2023
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8DGB
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) Q192T Mutant in Complex with Inhibitor GC376 | 分子名称: | (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5 | 著者 | Lewandowski, E.M, Jacobs, L.M.C, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-23 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir. Acs Cent.Sci., 9, 2023
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8DCZ
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) M165Y Mutant in Complex with Nirmatrelvir | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Lewandowski, E.M, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-17 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir. Acs Cent.Sci., 9, 2023
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8DD1
| SARS-CoV-2 Main Protease (Mpro) H164N Mutant in Complex with Inhibitor GC376 | 分子名称: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5 | 著者 | Lewandowski, E.M, Butler, S.G, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-17 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir. Acs Cent.Sci., 9, 2023
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8DFN
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) H164N Mutant | 分子名称: | 3C-like proteinase nsp5 | 著者 | Lewandowski, E.M, Butler, S.G, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-22 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir. Acs Cent.Sci., 9, 2023
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8DFE
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) S144L Mutant | 分子名称: | 3C-like proteinase nsp5 | 著者 | Lewandowski, E.M, Jacobs, L.M.C, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-22 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir. Acs Cent.Sci., 9, 2023
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8DD9
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) S144L Mutant in Complex with Inhibitor GC376 | 分子名称: | (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5 | 著者 | Lewandowski, E.M, Jacobs, L.M.C, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-17 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir. Acs Cent.Sci., 9, 2023
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6W54
| Crystal Structure of Gallic Acid Decarboxylase from Arxula adeninivorans | 分子名称: | 4-NITROCATECHOL, COBALT (II) ION, Gallate decarboxylase, ... | 著者 | Zeug, M, Marckovic, N, Iancu, C.V, Tripp, J, Oreb, M, Choe, J. | 登録日 | 2020-03-12 | 公開日 | 2021-02-17 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crystal structures of non-oxidative decarboxylases reveal a new mechanism of action with a catalytic dyad and structural twists. Sci Rep, 11, 2021
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6WZT
| CryoEM structure of influenza hemagglutinin A/Victoria/361/2011 in complex with cyno antibody 3B10 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cyno antibody heavy chain, ... | 著者 | Qiu, Y, Zhou, Y, Darricarrere, N. | 登録日 | 2020-05-14 | 公開日 | 2021-03-10 | 最終更新日 | 2021-03-17 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA stem vaccines in nonhuman primates. Sci Transl Med, 13, 2021
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6XGC
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6NFJ
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6XKR
| Structure of Sasanlimab Fab in complex with PD-1 | 分子名称: | GLYCEROL, Programmed cell death protein 1, Sasanlimab Fab Heavy chain, ... | 著者 | Kimberlin, C.R, Chin, S.M. | 登録日 | 2020-06-27 | 公開日 | 2020-09-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Pharmacologic Properties and Preclinical Activity of Sasanlimab, A High-affinity Engineered Anti-Human PD-1 Antibody. Mol.Cancer Ther., 19, 2020
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3C1C
| The effect of H3 K79 dimethylation and H4 K20 trimethylation on nucleosome and chromatin structure | 分子名称: | Histone 2, H2bf, Histone H2A type 1, ... | 著者 | Lu, X, Simon, M, Chodaparambil, J, Hansen, J, Shokat, K, Luger, K. | 登録日 | 2008-01-22 | 公開日 | 2008-10-07 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure. Nat.Struct.Mol.Biol., 15, 2008
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