6XKR

Structure of Sasanlimab Fab in complex with PD-1

Summary for 6XKR

• Entry DOI: 10.2210/pdb6xkr/pdb
• Descriptor: Sasanlimab Fab Heavy chain, Sasanlimab Fab Light chain, Programmed cell death protein 1, ... (5 entities in total)
• Functional Keywords: anti-pd-1, fab, complex, immuno-oncology, antitumor protein, antitumor protein-immune system complex, antitumor protein/immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 3
• Total formula weight: 65490.76

Authors

Kimberlin, C.R.,Chin, S.M. (deposition date: 2020-06-27, release date: 2020-09-09, Last modification date: 2023-10-18)

• Primary citation: Al-Khami, A.A.,Youssef, S.,Abdiche, Y.,Nguyen, H.,Chou, J.,Kimberlin, C.R.,Chin, S.M.,Kamperschroer, C.,Jessen, B.,Kern, B.,Budimir, N.,Dillon, C.P.,Xu, A.,Clark, J.D.,Chou, J.,Kraynov, E.,Rajpal, A.,Lin, J.C.,Salek-Ardakani, S.; Pharmacologic Properties and Preclinical Activity of Sasanlimab, A High-affinity Engineered Anti-Human PD-1 Antibody.; Mol.Cancer Ther., 19:2105-2116, 2020; PubMed: 32847983; DOI: 10.1158/1535-7163.MCT-20-0093

Experimental method

X-RAY DIFFRACTION (2.59 Å)