6XKR

Structure of Sasanlimab Fab in complex with PD-1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	H	Sasanlimab Fab Heavy chain	polymer	231	24860.9	1		Homo sapiens
2	L	Sasanlimab Fab Light chain	polymer	220	24372.9	1		Homo sapiens
3	P	Programmed cell death protein 1	polymer	141	15796.5	1	UniProt (Q15116) Pfam (PF07686) In PDB	Homo sapiens (Human)	hPD-1
4	H, L	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
5		water	water		18.0	107	Chemie (HOH)

Sequence modifications

P: 32 - 160 (UniProt: Q15116)

PDB	External Database	Details
Gly 161	-	expression tag
Ser 162	-	expression tag
Gly 163	-	expression tag
Ser 164	-	expression tag
His 165	-	expression tag
His 166	-	expression tag
His 167	-	expression tag
His 168	-	expression tag
His 169	-	expression tag
His 170	-	expression tag
His 171	-	expression tag
His 172	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	65030.3
Non-Polymers*	Number of molecules	5
	Total formula weight	460.5
All*	Total formula weight	65490.8

*Water molecules are not included.