6XKR

Structure of Sasanlimab Fab in complex with PD-1

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0016020	cellular_component	membrane
P	0050777	biological_process	negative regulation of immune response

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue GOL H 301

Chain	Residue
H	PRO41
H	ALA172
H	VAL173
H	LEU174
H	HOH411

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site_id	AC2
Number of Residues	2
Details	binding site for residue GOL H 302

Chain	Residue
H	PRO217
H	LYS218

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site_id	AC3
Number of Residues	10
Details	binding site for residue GOL L 301

Chain	Residue
H	SER181
H	LEU182
H	SER183
L	GLN166
L	SER168
L	SER182
L	SER183
L	THR184
H	PHE170
H	PRO171

---

site_id	AC4
Number of Residues	5
Details	binding site for residue GOL L 302

Chain	Residue
L	SER14
L	LYS113
L	ARG114
L	THR115
L	SER209

---

site_id	AC5
Number of Residues	3
Details	binding site for residue GOL L 303

Chain	Residue
L	GLY106
L	GLY107
L	HOH416

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR198-HIS204
L	TYR198-HIS204

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Region: {"description":"Interaction with CD274/PDCD1L1","evidences":[{"source":"PubMed","id":"26602187","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	25
Details	Region: {"description":"Pembrolizumab binding","evidences":[{"source":"PubMed","id":"27325296","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27734966","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5B8C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JXE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28165004","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28165004","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5WT9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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