8DGB
Crystal Structure of SARS-CoV-2 Main Protease (Mpro) Q192T Mutant in Complex with Inhibitor GC376
Summary for 8DGB
Entry DOI | 10.2210/pdb8dgb/pdb |
Descriptor | 3C-like proteinase nsp5, (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid (3 entities in total) |
Functional Keywords | protease, sars-cov-2, mpro, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 |
Total number of polymer chains | 2 |
Total formula weight | 68568.14 |
Authors | Lewandowski, E.M.,Jacobs, L.M.C.,Hu, Y.,Tan, H.,Wang, J.,Chen, Y. (deposition date: 2022-06-23, release date: 2022-07-13, Last modification date: 2023-10-25) |
Primary citation | Hu, Y.,Lewandowski, E.M.,Tan, H.,Zhang, X.,Morgan, R.T.,Zhang, X.,Jacobs, L.M.C.,Butler, S.G.,Gongora, M.V.,Choy, J.,Deng, X.,Chen, Y.,Wang, J. Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir. Acs Cent.Sci., 9:1658-1669, 2023 Cited by PubMed: 37637734DOI: 10.1021/acscentsci.3c00538 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.87 Å) |
Structure validation
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