8D8Q

SARS-CoV-2 Spike RBD in complex with DMAbs 2130 and 2196

Summary for 8D8Q

• Entry DOI: 10.2210/pdb8d8q/pdb
• EMDB information: 27254 27255
• Descriptor: 2130 heavy chain, 2130 light chain, Spike glycoprotein, ... (6 entities in total)
• Functional Keywords: covid-19, sars-cov-2, spike, rbd, igg, dmab, antibody cocktail, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 228447.86

Authors

Du, J.,Cui, J.,Pallesen, J. (deposition date: 2022-06-08, release date: 2022-10-19)

• Primary citation: Parzych, E.M.,Du, J.,Ali, A.R.,Schultheis, K.,Frase, D.,Smith, T.R.F.,Cui, J.,Chokkalingam, N.,Tursi, N.J.,Andrade, V.M.,Warner, B.M.,Gary, E.N.,Li, Y.,Choi, J.,Eisenhauer, J.,Maricic, I.,Kulkarni, A.,Chu, J.D.,Villafana, G.,Rosenthal, K.,Ren, K.,Francica, J.R.,Wootton, S.K.,Tebas, P.,Kobasa, D.,Broderick, K.E.,Boyer, J.D.,Esser, M.T.,Pallesen, J.,Kulp, D.W.,Patel, A.,Weiner, D.B.; DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2.; Nat Commun, 13:5886-5886, 2022; PubMed: 36202799; DOI: 10.1038/s41467-022-33309-6

Experimental method

ELECTRON MICROSCOPY (4.2 Å)