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KINESIN (MONOMERIC) FROM RATTUS NORVEGICUS
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, KINESIN, SULFATE ION
Authors:	Sack, S, Muller, J, Kozielski, F, Marx, A, Thormahlen, M, Biou, V, Mandelkow, E.-M, Brady, S.T, Mandelkow, E.
Deposit date:	1997-04-28
Release date:	1998-04-08
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	X-ray structure of motor and neck domains from rat brain kinesin. Biochemistry, 36, 1997

9QRP

Thermus thermophilus seryl-tRNA synthetase bound to tRNA(ser)(GGA) and seryl-adenylate analogue.
Descriptor:	5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, MANGANESE (II) ION, SULFATE ION, ...
Authors:	Cusack, S.
Deposit date:	2025-04-04
Release date:	2025-05-14
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	The crystal structure of the ternary complex of T.thermophilus seryl-tRNA synthetase with tRNA(Ser) and a seryl-adenylate analogue reveals a conformational switch in the active site. EMBO J, 15, 1996

9QMP

E.coli seryl-tRNA synthetase
Descriptor:	Serine--tRNA ligase
Authors:	Cusack, S.
Deposit date:	2025-03-24
Release date:	2025-05-14
Method:	X-RAY DIFFRACTION (2.48 Å)
Cite:	A second class of synthetase structure revealed by X-ray analysis of Escherichia coli seryl-tRNA synthetase at 2.5 A. Nature, 347, 1990

7ALP

Severe fever with thrombocytopenia syndrome virus (Phenuiviridae) L protein
Descriptor:	MAGNESIUM ION, Replicase
Authors:	Cusack, S, Rosenthal, M.
Deposit date:	2020-10-07
Release date:	2021-04-21
Last modified:	2024-05-15
Method:	ELECTRON MICROSCOPY (3.4 Å)
Cite:	Errors in the deposited SFTSV L protein structure. Nat Microbiol, 6, 2021

1H3N

Leucyl-tRNA synthetase from Thermus thermophilus complexed with a sulphamoyl analogue of leucyl-adenylate
Descriptor:	LEUCINE, LEUCYL-TRNA SYNTHETASE, SULFATE ION, ...
Authors:	Cusack, S, Yaremchuk, A, Tukalo, M.
Deposit date:	2002-09-11
Release date:	2002-09-27
Last modified:	2024-05-08
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	The 2A Structure of Leucyl-tRNA Synthetase and its Complex with a Leucyl-Adenylate Analogue Embo J., 19, 2000

9F2R

Influenza A/H17N10 polymerase with bound promoter and 3' end of template in active site
Descriptor:	3' end of the promoter vRNA, 5' end of the promoter vRNA, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:	Cusack, S, Drncova, P.
Deposit date:	2024-04-23
Release date:	2024-09-18
Method:	X-RAY DIFFRACTION (1.959 Å)
Cite:	High-resolution structure of a replication-initiation like configuration of influenza polymerase active site visualises the essential role of a conserved dibasic motif in the PA subunit To Be Published

9F37

Replication-like initiation state of influenza polymerase with GTP and CTP at respectively the -1 and +1 positions (strain A/little yellow-shouldered bat/Guatemala/060/2010/H17N10)
Descriptor:	3' end of the vRNA promoter, 5' end of the vRNA promoter, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:	Cusack, S, Drncova, P.
Deposit date:	2024-04-25
Release date:	2024-09-18
Method:	X-RAY DIFFRACTION (1.905 Å)
Cite:	High-resolution structure of a replication-initiation like configuration of influenza polymerase active site visualises the essential role of a conserved dibasic motif in the PA subunit Biorxiv, 2024

1SET

CRYSTAL STRUCTURES AT 2.5 ANGSTROMS RESOLUTION OF SERYL-TRNA SYNTHETASE COMPLEXED WITH TWO DIFFERENT ANALOGUES OF SERYL-ADENYLATE
Descriptor:	5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, SERYL-tRNA SYNTHETASE
Authors:	Cusack, S, Belrhali, H.
Deposit date:	1994-02-21
Release date:	1994-07-31
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.55 Å)
Cite:	Crystal structures at 2.5 angstrom resolution of seryl-tRNA synthetase complexed with two analogs of seryl adenylate. Science, 263, 1994

1SES

CRYSTAL STRUCTURES AT 2.5 ANGSTROMS RESOLUTION OF SERYL-TRNA SYNTHETASE COMPLEXED WITH TWO DIFFERENT ANALOGUES OF SERYL-ADENYLATE
Descriptor:	ADENOSINE MONOPHOSPHATE, SERYL-HYDROXAMATE-ADENOSINE MONOPHOSPHATE, SERYL-tRNA SYNTHETASE
Authors:	Cusack, S, Belrhali, H.
Deposit date:	1994-02-21
Release date:	1994-07-31
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Crystal structures at 2.5 angstrom resolution of seryl-tRNA synthetase complexed with two analogs of seryl adenylate. Science, 263, 1994

6EUX

Structure of the midlink and cap-binding domains of influenza B polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
Descriptor:	(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2
Authors:	Cusack, S, Gaudon, S.
Deposit date:	2017-10-31
Release date:	2017-12-13
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

6EUY

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
Descriptor:	(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2, SULFATE ION
Authors:	Cusack, S, Gaudon, S.
Deposit date:	2017-10-31
Release date:	2017-12-13
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

6EUW

Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor
Descriptor:	(2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, GLYCEROL, Polymerase basic protein 2
Authors:	Cusack, S, Gaudon, S.
Deposit date:	2017-10-31
Release date:	2017-12-13
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (1 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

1OBC

LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A POST-TRANSFER EDITING SUBSTRATE ANALOGUE
Descriptor:	2'-AMINO-2'-DEOXYADENOSINE, LEUCINE, LEUCYL-TRNA SYNTHETASE, ...
Authors:	Cusack, S, Yaremchuk, A, Tukalo, M.
Deposit date:	2003-01-30
Release date:	2003-05-09
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase Mol.Cell, 11, 2003

1OBH

LEUCYL-TRNA SYNTHETASE FROM THERMUS THERMOPHILUS COMPLEXED WITH A PRE-TRANSFER EDITING SUBSTRATE ANALOGUE IN BOTH SYNTHETIC ACTIVE SITE AND EDITING SITE
Descriptor:	LEUCYL-TRNA SYNTHETASE, MERCURY (II) ION, NORVALINE, ...
Authors:	Cusack, S, Yaremchuk, A, Tukalo, M.
Deposit date:	2003-01-31
Release date:	2003-05-09
Last modified:	2024-11-20
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Structural and Mechanistic Basis of Pre- and Posttransfer Editing by Leucyl-tRNA Synthetase Mol.Cell, 11, 2003

6EUV

Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (VX-787)
Descriptor:	(2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, NICKEL (II) ION, Polymerase basic protein 2
Authors:	Cusack, S, Lethier, M.
Deposit date:	2017-10-31
Release date:	2017-12-13
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors. Nucleic Acids Res., 46, 2018

6TU5

Influenza A/H7N9 polymerase core (apo)
Descriptor:	MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:	Cusack, S, Pflug, A.
Deposit date:	2020-01-02
Release date:	2020-04-15
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (3.325 Å)
Cite:	A Structure-Based Model for the Complete Transcription Cycle of Influenza Polymerase. Cell, 181, 2020

6Z6B

Structure of full-length La Crosse virus L protein (polymerase)
Descriptor:	RNA (5'-R(GPCPUPAPCPUPAPA)-3'), RNA (5'-R(PAPGPUPAPGPUPGPUPGPC)-3'), RNA (5'-R(PUPUPAPGPUPAPGPUPAPCPAPCPUPAPCPU)-3'), ...
Authors:	Cusack, S, Gerlach, P, Reguera, J.
Deposit date:	2020-05-28
Release date:	2020-07-29
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (3.961 Å)
Cite:	Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes. Nat Commun, 11, 2020

6F7J

Crystal structure of Human ARS2 residues 171-270 + 408-763
Descriptor:	Serrate RNA effector molecule homolog
Authors:	Cusack, S, Schulze, W.M.
Deposit date:	2017-12-10
Release date:	2018-05-09
Last modified:	2024-05-08
Method:	X-RAY DIFFRACTION (3.22 Å)
Cite:	Structural analysis of human ARS2 as a platform for co-transcriptional RNA sorting. Nat Commun, 9, 2018

4WSB

Bat Influenza A polymerase with bound vRNA promoter
Descriptor:	Influenza A polymerase vRNA promoter 3' end, Influenza A polymerase vRNA promoter 5' end, PHOSPHATE ION, ...
Authors:	Cusack, S, Pflug, A, Guilligay, D, Reich, S.
Deposit date:	2014-10-26
Release date:	2014-11-19
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	Structural insight into cap-snatching and RNA synthesis by influenza polymerase. Nature, 516, 2014

8BE0

Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the C +1 position
Descriptor:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-10-20
Release date:	2022-12-28
Last modified:	2025-07-09
Method:	ELECTRON MICROSCOPY (2.34 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

8BDR

Early transcription elongation state of influenza B/Mem polymerase backtracked due to double incoproation of nucleotide analogue T1106 and with singly incoporated T1106 at the U +1 position
Descriptor:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-10-19
Release date:	2022-12-28
Last modified:	2025-07-02
Method:	ELECTRON MICROSCOPY (2.7 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

8BEK

Early transcription elongation state of influenza A/H7N9 backtracked polymerase with singly incoporated T1106 at the U +1 position
Descriptor:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-10-21
Release date:	2022-12-28
Last modified:	2025-07-02
Method:	ELECTRON MICROSCOPY (2.86 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

8BF5

Early transcription elongation state of influenza A/H7N9 polymerase stalled with incoming GTP analogue
Descriptor:	3' vRNA, 5' vRNA, MAGNESIUM ION, ...
Authors:	Cusack, S, Kouba, T.
Deposit date:	2022-10-24
Release date:	2022-12-28
Last modified:	2025-07-09
Method:	ELECTRON MICROSCOPY (2.96 Å)
Cite:	Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42, 2023

7Z43

Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 1B and 2B
Descriptor:	PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:	Cusack, S, Drncova, P.
Deposit date:	2022-03-03
Release date:	2022-05-11
Last modified:	2024-11-13
Method:	X-RAY DIFFRACTION (3.123 Å)
Cite:	Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD. Plos Pathog., 18, 2022

7Z42

Influenza B polymerase with Pol II pSer5 CTD peptide mimic bound in site 2B
Descriptor:	DNA-directed RNA polymerase II subunit RPB1, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:	Cusack, S, Drncova, P.
Deposit date:	2022-03-03
Release date:	2022-05-18
Last modified:	2024-11-13
Method:	X-RAY DIFFRACTION (2.418 Å)
Cite:	Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD. Plos Pathog., 18, 2022

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Displayed results:	25
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