8BEK

Early transcription elongation state of influenza A/H7N9 backtracked polymerase with singly incoporated T1106 at the U +1 position

Summary for 8BEK

Entry DOI	10.2210/pdb8bek/pdb
Related	7QTL
EMDB information	16006
Descriptor	Polymerase acidic protein, RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 2, ... (9 entities in total)
Functional Keywords	influenza, viral rna-dependent rna polymerase; antiviral drug; nucleoside analogue; t705 (favipiravir); t1106; cap-dependent transcription; backtracking;, viral protein
Biological source	Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)) More
Total number of polymer chains	6
Total formula weight	272772.04
Authors	Cusack, S.,Kouba, T. (deposition date: 2022-10-21, release date: 2022-12-28, Last modification date: 2024-07-24)
Primary citation	Kouba, T.,Dubankova, A.,Drncova, P.,Donati, E.,Vidossich, P.,Speranzini, V.,Pflug, A.,Huchting, J.,Meier, C.,De Vivo, M.,Cusack, S. Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106. Cell Rep, 42:111901-111901, 2023 Cited by PubMed: 36596301 DOI: 10.1016/j.celrep.2022.111901 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.86 Å)

Structure validation