6OE1
 
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6OE0
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6ODZ
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8DYP
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4YI3
 | | Crystal structure of Gpb in complex with 4a | | Descriptor: | DIMETHYL SULFOXIDE, Glycogen phosphorylase, muscle form, ... | | Authors: | Kantsadi, A.L, Chatzileontiadou, D.S.M, Stravodimos, G.A, Leonidas, D.D. | | Deposit date: | 2015-02-27 | | Release date: | 2015-11-18 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Glycogen phosphorylase as a target for type 2 diabetes: synthetic, biochemical, structural and computational evaluation of novel N-acyl-N -( beta-D-glucopyranosyl) urea inhibitors.
Curr Top Med Chem, 15, 2015
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7URF
 | | Human HHAT H379C in complex with SHH N-terminal peptide | | Descriptor: | 3H02 heavy chain, 3H02 light chain, Digitonin, ... | | Authors: | Liu, Y, Qi, X, Li, X. | | Deposit date: | 2022-04-21 | | Release date: | 2022-07-20 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Mechanisms and inhibition of Porcupine-mediated Wnt acylation.
Nature, 607, 2022
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7URE
 | | Human PORCN in complex with palmitoleoylated WNT3A peptide | | Descriptor: | 2C11 heavy chain, 2C11 light chain, Digitonin, ... | | Authors: | Liu, Y, Qi, X, Li, X. | | Deposit date: | 2022-04-21 | | Release date: | 2022-07-20 | | Last modified: | 2024-12-25 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Mechanisms and inhibition of Porcupine-mediated Wnt acylation.
Nature, 607, 2022
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7URA
 | | Human PORCN in complex with Palmitoleoyl-CoA | | Descriptor: | 2C11 heavy chain, 2C11 light chain, CHOLESTEROL, ... | | Authors: | Liu, Y, Qi, X, Li, X. | | Deposit date: | 2022-04-21 | | Release date: | 2022-07-20 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.11 Å) | | Cite: | Mechanisms and inhibition of Porcupine-mediated Wnt acylation.
Nature, 607, 2022
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7URC
 | | Human PORCN in complex with LGK974 | | Descriptor: | 2-[(2P)-2',3-dimethyl[2,4'-bipyridin]-5-yl]-N-[(5P)-5-(pyrazin-2-yl)pyridin-2-yl]acetamide, 2C11 heavy chain, 2C11 light chain, ... | | Authors: | Liu, Y, Qi, X, Li, X. | | Deposit date: | 2022-04-21 | | Release date: | 2022-07-20 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | Mechanisms and inhibition of Porcupine-mediated Wnt acylation.
Nature, 607, 2022
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7URD
 | | Human PORCN in complex with LGK974 and WNT3A peptide | | Descriptor: | 2-[(2P)-2',3-dimethyl[2,4'-bipyridin]-5-yl]-N-[(5P)-5-(pyrazin-2-yl)pyridin-2-yl]acetamide, 2C11 heavy chain, 2C11 light chain, ... | | Authors: | Liu, Y, Qi, X, Li, X. | | Deposit date: | 2022-04-21 | | Release date: | 2022-07-20 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (2.92 Å) | | Cite: | Mechanisms and inhibition of Porcupine-mediated Wnt acylation.
Nature, 607, 2022
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7VOI
 | | Structure of the human CNOT1(MIF4G)-CNOT6L-CNOT7 complex | | Descriptor: | CCR4-NOT transcription complex subunit 1, CCR4-NOT transcription complex subunit 6-like, CCR4-NOT transcription complex subunit 7 | | Authors: | Bartlam, M, Zhang, Q. | | Deposit date: | 2021-10-13 | | Release date: | 2022-06-01 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (4.38 Å) | | Cite: | Structure of the human Ccr4-Not nuclease module using X-ray crystallography and electron paramagnetic resonance spectroscopy distance measurements.
Protein Sci., 31, 2022
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4YI5
 | | Crystal structure of Gpb in complex with 4b | | Descriptor: | Glycogen phosphorylase, muscle form, INOSINIC ACID, ... | | Authors: | Kantsadi, A.L, Chatzileontiadou, D.S.M, Stravodimos, G.A, Leonidas, D.D. | | Deposit date: | 2015-02-27 | | Release date: | 2015-11-18 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Glycogen phosphorylase as a target for type 2 diabetes: synthetic, biochemical, structural and computational evaluation of novel N-acyl-N -( beta-D-glucopyranosyl) urea inhibitors.
Curr Top Med Chem, 15, 2015
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4ZIA
 | | Crystal Structure of STAT3 N-terminal domain | | Descriptor: | FORMIC ACID, MAGNESIUM ION, NICKEL (II) ION, ... | | Authors: | Hu, T, Chopra, R. | | Deposit date: | 2015-04-28 | | Release date: | 2015-07-29 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional Activity.
Mol.Cell.Biol., 35, 2015
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8DKE
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8DKW
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8DKI
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8DKX
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8DKM
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5N5K
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5D9E
 | | Crystal Structure of the Proline-rich Lasso Peptide Caulosegnin II | | Descriptor: | CHLORIDE ION, Caulosegnin II | | Authors: | Fage, C.D, Hegemann, J.D, Harms, K, Marahiel, M.A. | | Deposit date: | 2015-08-18 | | Release date: | 2016-02-17 | | Last modified: | 2025-04-09 | | Method: | X-RAY DIFFRACTION (0.859 Å) | | Cite: | The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II.
Mol Biosyst, 12, 2016
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7SV1
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7SV8
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7SUY
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7SUW
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5N5J
 | | Human MMP12 in complex with 3-(5-(1,2-dithiolan-3-yl)pentanamido)propane-1-sulfonate | | Descriptor: | 3-[5-[(3~{S})-1,2-dithiolan-3-yl]pentanoylamino]propane-1-sulfonic acid, ACETOHYDROXAMIC ACID, CALCIUM ION, ... | | Authors: | Calderone, V. | | Deposit date: | 2017-02-14 | | Release date: | 2017-11-01 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX).
J. Med. Chem., 60, 2017
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