7SUW

Carbonic Anhydrase IX-mimic with 2-((3-Aminopropyl)(phenethyl)amino)-N-(furan-2-ylmethyl)-N-(4-sulfamoylphenethyl)acetamide

Summary for 7SUW

Entry DOI	10.2210/pdb7suw/pdb
Descriptor	Carbonic anhydrase 2, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ZINC ION, ... (5 entities in total)
Functional Keywords	inhibitor, carbonic anhydrase, metal binding protein, lyase-inhibitor complex, lyase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29545.62
Authors	McKenna, R.,Combs, J.E. (deposition date: 2021-11-18, release date: 2022-04-06, Last modification date: 2023-10-18)
Primary citation	Bonardi, A.,Bua, S.,Combs, J.,Lomelino, C.,Andring, J.,Osman, S.M.,Toti, A.,Di Cesare Mannelli, L.,Gratteri, P.,Ghelardini, C.,McKenna, R.,Nocentini, A.,Supuran, C.T. The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII. J Enzyme Inhib Med Chem, 37:930-939, 2022 Cited by PubMed: 35306936 DOI: 10.1080/14756366.2022.2053526 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.456 Å)

Structure validation