6OE0

Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects

Summary for 6OE0

Entry DOI	10.2210/pdb6oe0/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, 2-(2,4-dioxo-1,3-diazaspiro[4.6]undecan-3-yl)-N-(4-sulfamoylphenyl)acetamide, ... (5 entities in total)
Functional Keywords	carbonic anhydrase inhibitors, metalloenzymes, organoselenium, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29841.01
Authors	Peat, T.S. (deposition date: 2019-03-27, release date: 2019-06-12, Last modification date: 2023-10-11)
Primary citation	Angeli, A.,Di Cesare Mannelli, L.,Ghelardini, C.,Peat, T.S.,Bartolucci, G.,Menicatti, M.,Carta, F.,Supuran, C.T. Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects. Eur.J.Med.Chem., 177:188-197, 2019 Cited by PubMed: 31136893 DOI: 10.1016/j.ejmech.2019.05.058 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation