5N5K
Human catalytic MMP-12 in complex with 5-(1,2-dithiolan-3-yl)-N-(3-hydroxypropyl)pentanamide
Summary for 5N5K
Entry DOI | 10.2210/pdb5n5k/pdb |
Descriptor | Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | mmp-12, lipoic acid, inhibitor, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Secreted, extracellular space, extracellular matrix : P39900 |
Total number of polymer chains | 1 |
Total formula weight | 17919.85 |
Authors | Calderone, V. (deposition date: 2017-02-14, release date: 2017-11-01, Last modification date: 2024-01-17) |
Primary citation | Fragai, M.,Comito, G.,Di Cesare Mannelli, L.,Gualdani, R.,Calderone, V.,Louka, A.,Richichi, B.,Francesconi, O.,Angeli, A.,Nocentini, A.,Gratteri, P.,Chiarugi, P.,Ghelardini, C.,Tadini-Buoninsegni, F.,Supuran, C.T.,Nativi, C. Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX). J. Med. Chem., 60:9003-9011, 2017 Cited by PubMed: 29048889DOI: 10.1021/acs.jmedchem.7b01237 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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