5N5K
Human catalytic MMP-12 in complex with 5-(1,2-dithiolan-3-yl)-N-(3-hydroxypropyl)pentanamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Macrophage metalloelastase | polymer | 156 | 17330.3 | 1 | UniProt (P39900) Pfam (PF00413) | Homo sapiens (Human) | MME,Macrophage elastase,hME,Matrix metalloproteinase-12,MMP-12 |
| 2 | B, C (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, E, F (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 4 | G (A) | ACETOHYDROXAMIC ACID | non-polymer | 75.1 | 1 | Chemie (HAE) | |||
| 5 | H (A) | 5-[(3~{S})-1,2-dithiolan-3-yl]-~{N}-(3-oxidanylpropyl)pentanamide | non-polymer | 263.4 | 1 | Chemie (8NW) | |||
| 6 | I (A) | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
A: 108 - 263 (UniProt: P39900)
| PDB | External Database | Details |
|---|---|---|
| Asp 171 | Phe 171 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 17330.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 589.5 | |
| All* | Total formula weight | 17919.8 |
