6ZOY
| Structure of Disulphide-stabilized SARS-CoV-2 Spike Protein Trimer (x1 disulphide-bond mutant, S383C, D985C, K986P, V987P, single Arg S1/S2 cleavage site) in Closed State | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Xiong, X, Qu, K, Scheres, S.H.W, Briggs, J.A.G. | Deposit date: | 2020-07-08 | Release date: | 2020-07-22 | Last modified: | 2021-06-02 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | A thermostable, closed SARS-CoV-2 spike protein trimer. Nat.Struct.Mol.Biol., 27, 2020
|
|
7AS5
| 126 helix bundle DNA nanostructure | Descriptor: | SCAFFOLD STRAND, STAPLE STRAND | Authors: | Kube, M, Kohler, F, Feigl, E, Nagel-Yuksel, B, Willner, E.M, Funke, J.J, Gerling, T, Stommer, P, Honemann, M.N, Martin, T.G, Scheres, S.H.W, Dietz, H. | Deposit date: | 2020-10-27 | Release date: | 2020-11-18 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (9.8 Å) | Cite: | Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution. Nat Commun, 11, 2020
|
|
7ART
| 48 helix bundle DNA origami brick | Descriptor: | SCAFFOLD STRAND, STAPLE STRAND | Authors: | Feigl, E, Kube, M, Kohler, F, Nagel-Yuksel, B, Willner, E.M, Funke, J.J, Gerling, T, Stommer, P, Honemann, M.N, Martin, T.G, Scheres, S.H.W, Dietz, H. | Deposit date: | 2020-10-26 | Release date: | 2020-11-11 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (10 Å) | Cite: | Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution. Nat Commun, 11, 2020
|
|
8BG9
| Murine amyloid-beta filaments with the Arctic mutation (E22G) from APP(NL-G-F) mouse brains | ABeta | Descriptor: | Amyloid-beta protein 40 | Authors: | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordber, A, Goedert, M, Scheres, S.H.W. | Deposit date: | 2022-10-27 | Release date: | 2023-01-18 | Last modified: | 2023-02-22 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145, 2023
|
|
8BG0
| Amyloid-beta tetrameric filaments with the Arctic mutation (E22G) from Alzheimer's disease brains | ABeta40 | Descriptor: | Amyloid-beta precursor protein | Authors: | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordber, A, Goedert, M, Scheres, S.H.W. | Deposit date: | 2022-10-27 | Release date: | 2023-01-18 | Last modified: | 2023-02-22 | Method: | ELECTRON MICROSCOPY (1.9 Å) | Cite: | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145, 2023
|
|
8BFZ
| Amyloid-beta 42 filaments extracted from the human brain with Arctic mutation (E22G) of Alzheimer's disease | ABeta42 | Descriptor: | Amyloid-beta precursor protein | Authors: | Yang, Y, Zhang, W.J, Murzin, A.G, Schweighauser, M, Huang, M, Lovestam, S.K.A, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Ghetti, B, Graff, C, Kumar, A, Nordberg, A, Goedert, M, Scheres, S.H.W. | Deposit date: | 2022-10-27 | Release date: | 2023-01-18 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains. Acta Neuropathol, 145, 2023
|
|
7ARV
| TwistTower_native-twist | Descriptor: | SCAFFOLD STRAND, STAPLE STRAND | Authors: | Kube, M, Kohler, F, Feigl, E, Nagel-Yuksel, B, Willner, E.M, Funke, J.J, Gerling, T, Stommer, P, Honemann, M.N, Martin, T.G, Scheres, S.H.W, Dietz, H. | Deposit date: | 2020-10-26 | Release date: | 2020-11-18 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (7.4 Å) | Cite: | Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution. Nat Commun, 11, 2020
|
|
7ARY
| Twist-Tower_twist-corrected-variant | Descriptor: | SCAFFOLD STRAND, STAPLE STRAND | Authors: | Kube, M, Kohler, F, Feigl, E, Nagel-Yuksel, B, Willner, E.M, Funke, J.J, Gerling, T, Stommer, P, Honemann, M.N, Martin, T.G, Scheres, S.H.W, Dietz, H. | Deposit date: | 2020-10-26 | Release date: | 2020-11-18 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (8.5 Å) | Cite: | Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution. Nat Commun, 11, 2020
|
|
8BYN
| Chronic traumatic encephalopathy tau filaments with PET ligand flortaucipir | Descriptor: | 7-(6-fluoranylpyridin-3-yl)-5~{H}-pyrido[4,3-b]indole, Microtubule-associated protein tau | Authors: | Shi, Y, Ghetti, B, Goedert, M, Scheres, S.H.W. | Deposit date: | 2022-12-13 | Release date: | 2023-01-11 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Cryo-EM Structures of Chronic Traumatic Encephalopathy Tau Filaments with PET Ligand Flortaucipir. J.Mol.Biol., 435, 2023
|
|
7ARE
| DNA origami pointer object v2 | Descriptor: | SCAFFOLD STRAND, STAPLE STRAND | Authors: | Thomas, M, Feigl, E, Kohler, F, Kube, M, Nagel-Yuksel, B, Willner, E.M, Funke, J.J, Gerling, T, Stommer, P, Honemann, M.N, Martin, T.G, Scheres, S.H.W, Dietz, H. | Deposit date: | 2020-10-24 | Release date: | 2020-11-18 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (7.4 Å) | Cite: | Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution. Nat Commun, 11, 2020
|
|
8QN7
| Amyloid-beta 40 type 1 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy | Descriptor: | Amyloid-beta A4 protein | Authors: | Yang, Y, Murzin, A.S, Peak-Chew, S.Y, Franco, C, Newell, K.L, Ghetti, B, Goedert, M, Scheres, S.H.W. | Deposit date: | 2023-09-25 | Release date: | 2023-12-13 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Cryo-EM structures of A beta 40 filaments from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid angiopathy. Acta Neuropathol Commun, 11, 2023
|
|
8QN6
| Amyloid-beta 40 type 2 filament from the leptomeninges of individual with Alzheimer's disease and cerebral amyloid angiopathy | Descriptor: | Amyloid-beta A4 protein | Authors: | Yang, Y, Murzin, A.S, Peak-Chew, S.Y, Franco, C, Newell, K.L, Ghetti, B, Goedert, M, Scheres, S.H.W. | Deposit date: | 2023-09-25 | Release date: | 2023-12-13 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Cryo-EM structures of A beta 40 filaments from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid angiopathy. Acta Neuropathol Commun, 11, 2023
|
|
8Q8S
| Tau - AD-THF | Descriptor: | Isoform Tau-D of Microtubule-associated protein tau | Authors: | Lovestam, S, Li, D, Scheres, S.H.W, Goedert, M. | Deposit date: | 2023-08-18 | Release date: | 2023-09-20 | Last modified: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (2.68 Å) | Cite: | Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
|
|
8Q8Z
| |
8Q9A
| |
8Q8E
| |
8Q8X
| |
8Q9B
| |
8QJJ
| CTE type II (tau intermediate amyloid) | Descriptor: | Isoform Tau-D of Microtubule-associated protein tau | Authors: | Lovestam, S, Scheres, S.H.W. | Deposit date: | 2023-09-13 | Release date: | 2023-10-18 | Last modified: | 2024-01-17 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Disease-specific tau filaments assemble via polymorphic intermediates. Nature, 625, 2024
|
|
8Q92
| P301S Tau Filaments from the Brains of PS19 Transgenic Mouse Line | Descriptor: | Microtubule-associated protein tau | Authors: | Schweighauser, M, Murzin, A.G, Macdonald, J, Lavenir, I, Crowther, R.A, Scheres, S.H.W, Goedert, M. | Deposit date: | 2023-08-19 | Release date: | 2023-10-11 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.05 Å) | Cite: | Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau. Acta Neuropathol Commun, 11, 2023
|
|
8Q96
| P301S Tau Filaments from the Brains of Tg2541 Transgenic Mouse Line | Descriptor: | Isoform Tau-E of Microtubule-associated protein tau, Unknown protein | Authors: | Schweighauser, M, Murzin, A.G, Macdonald, J, Lavenir, I, Crowther, R.A, Scheres, S.H.W, Goedert, M. | Deposit date: | 2023-08-19 | Release date: | 2023-10-11 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau. Acta Neuropathol Commun, 11, 2023
|
|
5N9Y
| The full-length structure of ZntB | Descriptor: | Zinc transport protein ZntB | Authors: | Cornelius, G, Stetsenko, A, Scheres, S.H.W, Slotboom, D.J, Guskov, A. | Deposit date: | 2017-02-27 | Release date: | 2017-11-15 | Last modified: | 2019-10-23 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | The structural basis of proton driven zinc transport by ZntB. Nat Commun, 8, 2017
|
|
6XYQ
| Multiple system atrophy Type II-2 alpha-synuclein filament | Descriptor: | Alpha-synuclein | Authors: | Schweighauser, M, Shi, Y, Tarutani, A, Kametani, F, Murzin, A.G, Ghetti, B, Matsubara, T, Tomita, T, Ando, T, Hasegawa, K, Murayama, S, Yoshida, M, Hasegawa, M, Scheres, S.H.W, Goedert, M. | Deposit date: | 2020-01-30 | Release date: | 2020-02-12 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Structures of alpha-synuclein filaments from multiple system atrophy. Nature, 585, 2020
|
|
6ZOZ
| Structure of Disulphide-stabilized SARS-CoV-2 Spike Protein Trimer (x1 disulphide-bond mutant, S383C, D985C, K986P, V987P, single Arg S1/S2 cleavage site) in Locked State | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BILIVERDINE IX ALPHA, ... | Authors: | Xiong, X, Qu, K, Scheres, S.H.W, Briggs, J.A.G. | Deposit date: | 2020-07-08 | Release date: | 2020-07-22 | Last modified: | 2022-03-02 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | A thermostable, closed SARS-CoV-2 spike protein trimer. Nat.Struct.Mol.Biol., 27, 2020
|
|
6ZP0
| Structure of SARS-CoV-2 Spike Protein Trimer (single Arg S1/S2 cleavage site) in Closed State | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Xiong, X, Qu, K, Scheres, S.H.W, Briggs, J.A.G. | Deposit date: | 2020-07-08 | Release date: | 2020-07-22 | Last modified: | 2021-06-02 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | A thermostable, closed SARS-CoV-2 spike protein trimer. Nat.Struct.Mol.Biol., 27, 2020
|
|