8Q96

P301S Tau Filaments from the Brains of Tg2541 Transgenic Mouse Line

Summary for 8Q96

Entry DOI	10.2210/pdb8q96/pdb
EMDB information	18269
Descriptor	Isoform Tau-E of Microtubule-associated protein tau, Unknown protein (3 entities in total)
Functional Keywords	p301s tau, frontotemporal dementia and parkinsonism linked to chromosome 17, transgenic mice, electron cryo-microscopy, protein fibril
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	12
Total formula weight	31481.08
Authors	Schweighauser, M.,Murzin, A.G.,Macdonald, J.,Lavenir, I.,Crowther, R.A.,Scheres, S.H.W.,Goedert, M. (deposition date: 2023-08-19, release date: 2023-10-11, Last modification date: 2023-10-18)
Primary citation	Schweighauser, M.,Murzin, A.G.,Macdonald, J.,Lavenir, I.,Crowther, R.A.,Scheres, S.H.W.,Goedert, M. Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau. Acta Neuropathol Commun, 11:160-160, 2023 Cited by PubMed: 37798679 DOI: 10.1186/s40478-023-01658-y PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.09 Å)

Structure validation