8BFZ

Amyloid-beta 42 filaments extracted from the human brain with Arctic mutation (E22G) of Alzheimer's disease | ABeta42

Summary for 8BFZ

• Entry DOI: 10.2210/pdb8bfz/pdb
• EMDB information: 16022
• Descriptor: Amyloid-beta precursor protein (1 entity in total)
• Functional Keywords: amyloid, filaments, amyloid-beta, arctic mutation, app, e22g, e693g, protein fibril
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 9040.17

Authors

Yang, Y.,Zhang, W.J.,Murzin, A.G.,Schweighauser, M.,Huang, M.,Lovestam, S.K.A.,Peak-Chew, S.Y.,Macdonald, J.,Lavenir, I.,Ghetti, B.,Graff, C.,Kumar, A.,Nordberg, A.,Goedert, M.,Scheres, S.H.W. (deposition date: 2022-10-27, release date: 2023-01-18, Last modification date: 2024-01-31)

• Primary citation: Yang, Y.,Zhang, W.,Murzin, A.G.,Schweighauser, M.,Huang, M.,Lovestam, S.,Peak-Chew, S.Y.,Saito, T.,Saido, T.C.,Macdonald, J.,Lavenir, I.,Ghetti, B.,Graff, C.,Kumar, A.,Nordberg, A.,Goedert, M.,Scheres, S.H.W.; Cryo-EM structures of amyloid-beta filaments with the Arctic mutation (E22G) from human and mouse brains.; Acta Neuropathol, 145:325-333, 2023; PubMed: 36611124; DOI: 10.1007/s00401-022-02533-1

Experimental method

ELECTRON MICROSCOPY (2.8 Å)